QuickView for HTR2C (gene)

Gene Symbol:

HTR2C Homo sapiens

Full name:

5-hydroxytryptamine receptor 2C

Synonyms:

5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine receptor 1C, serotonin 5-HT-1C receptor, serotonin 5-HT-2C receptor

Genomic Location:

Chr X: 113724807-114050880

Description:

This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second...

View Full Description

This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  CEBPA_01 ,  MYOD_01 ,  TAL1ALPHAE47_01 ,  GCATTTG_MIR105 ,  CCCAGAG_MIR326 ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  GCANCTGNY_MYOD_Q6 ,  CTTTGCA_MIR527 ,  TGAGATT_MIR216 ,  E2F_Q6_01 ,  AREB6_04 ,  TAGCTTT_MIR9 ,  MYB_Q5_01 ,  GGGAGGRR_MAZ_Q6 ,  CEBP_Q2 ,  TAL1BETAE47_01 ,  PAX4_02 ,  CAGGTG_E12_Q6 ,  TST1_01 ,  TGCCTTA_MIR124A ,  GTAAGAT_MIR200A ,  ACTGCCT_MIR34B ,  S8_01 ,  NKX25_02 ,  IRF_Q6 ,  NFY_Q6 ,  GCM_Q2 ,  TGCCAAR_NF1_Q6 ,  GCCNNNWTAAR_UNKNOWN ,  YCATTAA_UNKNOWN ,  AATGTGA_MIR23A_MIR23B ,  CEBP_Q3 ,  CETS1P54_01 ,  TAATTA_CHX10_01 ,  CCTGCTG_MIR214 ,  GR_01 ,  YTAAYNGCT_UNKNOWN ,  ATF1_Q6 ,  CHOP_01 ,  PIT1_Q6 ,  AFP1_Q6 ,  TAL1BETAITF2_01 ,  TACAATC_MIR508 ,  CAGCTG_AP4_Q5 ,  ISRE_01 ,  GTCTACC_MIR379 ,  AACTTT_UNKNOWN ,  GGCAGTG_MIR3243P ,  YNGTTNNNATT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  TCATCTC_MIR143

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-379 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-455 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496

View More

View Less

Cytogenetic Map:

Xq23

search → result