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QuickView for HTRA1 (gene)


Gene Symbol:
HTRA1 Homo sapiens Homo sapiens
Full name:
HtrA serine peptidase 1
Synonyms:
ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11, serine protease HTRA1, IGFBP5-protease, high-temperature requirement A serine peptidase 1, protease, serine, 11 (IGF binding)
Genomic Location:
Chr 10: 124211047-124264413
Description:
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of sus...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 10
10q26.13


Transcripts Names
NM_002775
Protein Names
Q9UNS5
D3DRE4
Q92743



GO Molecular Function

hydrolase activity | growth factor binding | catalytic activity | insulin-like growth factor binding | serine hydrolase activity | identical protein binding | protein binding | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | peptidase activity

GO Biological Process

negative regulation of immune system process | extracellular structure organization | developmental process involved in reproduction | proteolysis | chorionic trophoblast cell differentiation | regulation of immune system process | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of BMP signaling pathway | negative regulation of cellular process | cell differentiation | positive regulation of epithelial cell proliferation | cellular process | odontogenesis | negative regulation of signaling | reproductive system development | regulation of defense response to virus | regulation of cellular process | regulation of metabolic process | cellular component organization | regulation of cell proliferation | reproduction | extracellular matrix organization | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | negative regulation of defense response to virus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | regulation of BMP signaling pathway | regulation of gene expression | animal organ morphogenesis | regulation of nitrogen compound metabolic process | negative regulation of cellular response to growth factor stimulus | regulation of transcription by RNA polymerase II | dentinogenesis | regulation of cellular metabolic process | odontogenesis of dentin-containing tooth | positive regulation of cell proliferation | regulation of RNA metabolic process | regulation of cellular response to growth factor stimulus | protein metabolic process | negative regulation of transforming growth factor beta receptor signaling pathway | regulation of growth | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | organic substance metabolic process | animal organ development | chorion development | serine-type endopeptidase activity | serine-type peptidase activity | anatomical structure formation involved in morphogenesis | regulation of cell communication | negative regulation of signal transduction | regulation of transcription, DNA-templated | endopeptidase activity | regulation of epithelial cell proliferation | anatomical structure morphogenesis | reproductive structure development | developmental process | regulation of cell growth | placenta development | peptidase activity | extracellular matrix disassembly | regulation of cellular component organization | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

extracellular matrix | cell | cytoplasm | collagen-containing extracellular matrix | plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | cytosol | intracellular | membrane