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PubChem
| Name: | Halothane |
|---|---|
| PubChem Compound ID: | 3562 |
| Description: | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178) |
| Molecular formula: | C2HBrClF3 |
| Molecular weight: | 197.381 g/mol |
| Synonyms: |
Halothane (JP15/USP); 2,2,2-Trifluoro-1-chloro-1-bromoethane; Fluothane; Ethane, 1-bromo-1-chloro-2,2,2-trifluoro-; Narcotan; Ethane, 2-bromo-2-chloro-1,1, 1-trifluoro-; EINECS 205-796-5; Halotano [INN-Spanish]; 151-67-7; Halothane.
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DrugBank
Identification
| Name: | Halothane |
|---|---|
| Name (isomeric): | DB01159 |
| Drug Type: | small molecule |
| Description: | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178) |
| Synonyms: |
Ftuorotan; Ftorotan [Russian]; Narcotann Ne-Spofa [Russian]; Halothanum [INN-Latin]; Bromchlortrifluoraethanum; Fluorotane; Freon 123b1; 2-Bromo-2-Chloro-1,1,1-Trifluoroethane; Bromochlorotrifluoroethane; Halothan.
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| Brand: | Narcotane, Halsan, Phthorothanum, Rhodialothan, Anestan, Chalothane, Fluktan, Fluothane, Narkotan, Halotan, Halan, Halothane, Narcotan |
| Category: | Anesthetics, Inhalation, General Anesthetics, Anesthetics |
| CAS number: | 151-67-7 |
Pharmacology
| Indication: | For the induction and maintenance of general anesthesia |
|---|---|
| Pharmacology: |
Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediat...
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| Mechanism of Action: |
Halothane causes general anaethesia due to its actions on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility. Its immobilizing effects have been attributed to its binding to potassium channels in cholinergic neurons. Halothane's effect are also likely due to binding to NMDA and calcium channels, cau...
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| Biotransformation: | Halothane is metabolized in the liver, primarily by CYP2E1, and to a lesser extent by CYP3A4 and CYP2A6. |
| Toxicity: | Toxic effects of halothane include malignant hyperthermia and hepatitis. |
| Affected organisms: | Humans and other mammals |
Interactions
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