QuickView for Hepcidin (gene)

Gene Symbol:

Hamp Mus musculus

Full name:

hepcidin antimicrobial peptide

Synonyms:

Hamp1, Hepc, Hepc1, hepcidin, hepcidin antimicrobial peptide 1

Genomic Location:

Chr 7: 31727387-31729036

Description:

This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisce...

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This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisceral iron overlaod, with sparing of the spleen macrophages. Certain mutations in the human ortholog of this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis. This gene is located adjacent to a related hepcidin gene on chromosome 7.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA1_03 ,  GATA1_04 ,  TATA_C ,  STAT5A_01 ,  STAT5B_01 ,  EFC_Q6 ,  GATA_Q6 ,  TTCYNRGAA_STAT5B_01

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