QuickView for Hes1 (gene)

GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | chaperone binding | RNA polymerase II regulatory region DNA binding | E-box binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | identical protein binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | histone deacetylase binding | transcription coregulator activity | heterocyclic compound binding | N-box binding

GO Biological Process

RNA metabolic process | brain development | Notch signaling pathway | cell morphogenesis | forebrain radial glial cell differentiation | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | negative regulation of hematopoietic progenitor cell differentiation | S-shaped body morphogenesis | cell motility | pharyngeal system development | regulation of neurogenesis | developmental process involved in reproduction | regulation of inner ear receptor cell differentiation | regulation of cell development | morphogenesis of an epithelium | somatic stem cell population maintenance | positive regulation of embryonic development | positive regulation of peptidyl-tyrosine phosphorylation | cell-cell signaling involved in cell fate commitment | negative regulation of pro-B cell differentiation | negative regulation of glial cell proliferation | smooth muscle cell differentiation | regulation of immune system process | negative regulation of cellular process | trochlear nerve development | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | neural tube patterning | positive regulation of developmental process | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | cell differentiation | respiratory tube development | glomerulus development | nervous system development | regulation of hematopoietic progenitor cell differentiation | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | generation of neurons | mesenchyme development | blood vessel morphogenesis | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | negative regulation of gliogenesis | ascending aorta morphogenesis | midbrain-hindbrain boundary morphogenesis | localization | epithelial tube morphogenesis | cell maturation | heart morphogenesis | neuron development | reproductive system development | metanephric epithelium development | regulation of embryonic development | immune system development | negative regulation of nucleic acid-templated transcription | renal tubule morphogenesis | stem cell population maintenance | regulation of forebrain neuron differentiation | regulation of cell cycle | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | diencephalon development | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | metanephric nephron development | muscle structure development | muscle cell differentiation | ventricular septum morphogenesis | autonomic nervous system development | regulation of cellular process | regulation of metabolic process | gliogenesis | pituitary gland development | metanephric nephron morphogenesis | hepaticobiliary system development | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | establishment of cell polarity | cellular component organization | urogenital system development | rostrocaudal neural tube patterning | nephron tubule morphogenesis | head development | cranial nerve development | response to stimulus | thymus development | vasculature development | muscle cell development | cell morphogenesis involved in neuron differentiation | mesenchymal cell development | respiratory system development | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | cardiac neural crest cell development involved in heart development | regulation of cardioblast proliferation | positive regulation of JAK-STAT cascade | positive regulation of lymphocyte proliferation | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | vascular smooth muscle cell differentiation | tube morphogenesis | positive regulation of cell-cell adhesion | regulation of epithelial cell differentiation | positive regulation of cell activation | reproduction | cardiovascular system development | midbrain development | cellular nitrogen compound metabolic process | inner ear receptor cell differentiation | positive regulation of T cell activation | regulation of DNA binding | positive regulation of gliogenesis | metanephros morphogenesis | negative regulation of metabolic process | positive regulation of BMP signaling pathway | positive regulation of RNA biosynthetic process | cellular component assembly | negative regulation of hemopoiesis | regulation of cell adhesion | cellular biosynthetic process | kidney development | embryo development | adenohypophysis development | cell-cell signaling | regulation of oligodendrocyte differentiation | negative regulation of stomach neuroendocrine cell differentiation | regulation of pro-B cell differentiation | embryonic placenta development | blood vessel development | parasympathetic nervous system development | anterior/posterior pattern specification | neuron fate commitment | hair cell differentiation | regulation of nucleic acid-templated transcription | common bile duct development | locomotion | positive regulation of mononuclear cell proliferation | epithelial cell fate commitment | negative regulation of inner ear auditory receptor cell differentiation | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | ureteric bud development | multicellular organism development | cell migration | glomerulus vasculature development | inner ear receptor cell development | regulation of BMP signaling pathway | inner ear receptor cell stereocilium organization | inner ear auditory receptor cell differentiation | neuroepithelial cell differentiation | regulation of phosphorylation | kidney morphogenesis | regulation of mitotic cell cycle, embryonic | mechanoreceptor differentiation | regulation of T cell activation | telencephalon development | artery development | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of neuron differentiation | regulation of gene expression | kidney epithelium development | pancreas development | outflow tract morphogenesis | regulation of epidermis development | embryonic heart tube morphogenesis | auditory receptor cell fate commitment | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | animal organ morphogenesis | liver development | positive regulation of Notch signaling pathway | regulation of nitrogen compound metabolic process | placenta blood vessel development | regulation of Notch signaling pathway | negative regulation of forebrain neuron differentiation | positive regulation of STAT cascade | positive regulation of intracellular signal transduction | cardiocyte differentiation | transcription corepressor activity | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | radial glial cell differentiation | positive regulation of cell differentiation | negative regulation of epidermal cell differentiation | epidermal cell differentiation | stem cell differentiation | regulation of cell proliferation involved in heart morphogenesis | pharyngeal arch artery morphogenesis | biosynthetic process | labyrinthine layer development | neural tube development | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of T cell proliferation | cell differentiation involved in kidney development | glial cell differentiation | hindbrain development | mesonephric epithelium development | cardiac septum morphogenesis | epidermis development | negative regulation of inner ear receptor cell differentiation | labyrinthine layer blood vessel development | endocrine system development | cell morphogenesis involved in differentiation | mesonephros development | establishment or maintenance of cell polarity | sensory organ development | regulation of timing of cell differentiation | chordate embryonic development | cell communication | regulation of cellular metabolic process | metanephros development | renal tubule development | positive regulation of tyrosine phosphorylation of STAT protein | regulation of glial cell proliferation | regulation of protein metabolic process | positive regulation of signal transduction | kidney interstitial fibroblast differentiation | inner ear development | heart development | positive regulation of cell proliferation | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of stem cell differentiation | renal system development | regulation of cellular response to growth factor stimulus | embryonic morphogenesis | metanephric nephron tubule morphogenesis | positive regulation of mitotic cell cycle, embryonic | neuronal stem cell population maintenance | regulation of mitotic cell cycle | negative regulation of epithelial cell differentiation | nephron development | positive regulation of molecular function | neuron differentiation | embryonic organ morphogenesis | protein-containing complex assembly | ureteric bud morphogenesis | regulation of inner ear auditory receptor cell differentiation | ventricular septum development | oculomotor nerve development | DNA-binding transcription factor activity | regionalization | cardiac ventricle development | positive regulation of protein modification process | gland development | tissue morphogenesis | artery morphogenesis | regulation of hemopoiesis | regulation of JAK-STAT cascade | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | embryonic heart tube development | anatomical structure development | lateral inhibition | cell surface receptor signaling pathway | positive regulation of neurogenesis | aorta development | cell projection organization | metabolic process | positive regulation of cell development | cell fate commitment | mesenchymal cell differentiation | negative regulation of pancreatic A cell differentiation | inhibition of neuroepithelial cell differentiation | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | developmental maturation | negative regulation of transcription, DNA-templated | embryonic organ development | ear development | positive regulation of glial cell differentiation | hindbrain morphogenesis | forebrain generation of neurons | cell adhesion | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | neuron projection development | organic substance metabolic process | maintenance of cell number | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | forebrain development | negative regulation of neuron differentiation | nerve development | establishment of epithelial cell polarity | gene expression | metanephric tubule development | regulation of cell activation | regulation of heart morphogenesis | negative regulation of stem cell differentiation | regulation of phosphate metabolic process | positive regulation of astrocyte differentiation | positive regulation of binding | transcription, DNA-templated | aorta morphogenesis | lung development | stem cell development | comma-shaped body morphogenesis | smoothened signaling pathway | anatomical structure formation involved in morphogenesis | regulation of animal organ formation | regulation of glial cell differentiation | regulation of cell communication | regulation of lymphoid progenitor cell differentiation | regulation of gliogenesis | signaling | somite development | regulation of transcription, DNA-templated | renal interstitial fibroblast development | regulation of secondary heart field cardioblast proliferation | cell development | positive regulation of DNA binding | regulation of T cell proliferation | neuron fate determination | regulation of epithelial cell proliferation | positive regulation of phosphorylation | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | reproductive structure development | regulation of nervous system development | regulation of developmental process | metanephric tubule morphogenesis | segmentation | developmental process | vascular smooth muscle cell development | negative regulation of glial cell differentiation | cardiac septum development | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | cell fate determination | regulation of development, heterochronic | cochlea development | cardiac neural crest cell development involved in outflow tract morphogenesis | neural crest cell differentiation | transcription coregulator activity | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | cardiac chamber development | heterocycle metabolic process | somitogenesis | central nervous system development | in utero embryonic development | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | placenta development | regulation of astrocyte differentiation | negative regulation of oligodendrocyte differentiation | auditory receptor cell fate determination | negative regulation of cell development | metanephric nephron tubule development | circulatory system development | neural crest cell development | positive regulation of leukocyte cell-cell adhesion | nephron tubule development | negative regulation of cell differentiation | regulation of epidermal cell differentiation | regulation of timing of neuron differentiation | positive regulation of signaling | signal transduction | regulation of signaling | mesonephric tubule development | positive regulation of gene expression | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | midbrain-hindbrain boundary development | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular

PATHWAYS

PID_ATF2_PATHWAY | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | REACTOME_DEVELOPMENTAL_BIOLOGY | PID_CMYB_PATHWAY | PID_HES_HEY_PATHWAY | REACTOME_SIGNALING_BY_NOTCH | PID_FANCONI_PATHWAY | PID_DELTA_NP63_PATHWAY | REACTOME_SIGNALING_BY_NOTCH1

PROTEIN FAMILY

Orange domain | Myc-type, basic helix-loop-helix (bHLH) domain | Helix-loop-helix DNA-binding domain superfamily