QuickView for Hes5 (gene)

Gene Symbol:

HES5 Homo sapiens

Full name:

hes family bHLH transcription factor 5

Synonyms:

bHLHb38, transcription factor HES-5, class B basic helix-loop-helix protein 38, hairy and enhancer of split 5

Genomic Location:

Chr 1: 2450044-2451544

Description:

This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.

This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGACTT_MIR224 ,  TTTGTAG_MIR520D ,  GGCACAT_MIR455 ,  TCTATGA_MIR376A_MIR376B ,  AAAGGAT_MIR501

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-455

Cytogenetic Map:

1p36.32

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