QuickView for Hey2 (gene)

Gene Symbol:

HEY2 Homo sapiens

Full name:

hes related family bHLH transcription factor with YRPW motif 2

Synonyms:

CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32, hairy/enhancer-of-split related with YRPW motif protein 2, HES-related repressor protein 1, HES-related repressor protein 2, HESR-2, HRT-2, cardiovascular basic helix-loop-helix factor 1, cardiovascular helix-loop-helix factor 1, class B basic helix-loop-helix protein 32, hCHF1, hHRT2, hairy and enhancer of split-related protein 2, hairy-related transcription factor 2, hairy/enhancer-of-split related with YRPW motif 2, protein gridlock homolog

Genomic Location:

Chr 6: 126112425-126124108

Description:

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signa...

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This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTATGCA_MIR153 ,  CTTTGA_LEF1_Q2 ,  CTTTGTA_MIR524 ,  FOXJ2_01 ,  S8_01 ,  GGCAGCT_MIR22 ,  TGCACTT_MIR519C_MIR519B_MIR519A

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-448

Cytogenetic Map:

6q22.31

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