QuickView for Hif-1a (gene)

Gene Symbol:

HIF1A Homo sapiens

Full name:

hypoxia inducible factor 1 alpha subunit

Synonyms:

HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia-inducible factor 1-alpha, ARNT interacting protein, PAS domain-containing protein 8, basic-helix-loop-helix-PAS protein MOP1, class E basic helix-loop-helix protein 78, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1 alpha isoform I.3, hypoxia-inducible factor1alpha, member of PAS protein 1, member of PAS superfamily 1

Genomic Location:

Chr 14: 61231992-61284729

Description:

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angio...

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This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  TGIF_01 ,  AAGCCAT_MIR135A_MIR135B ,  TCANNTGAY_SREBP1_01 ,  HEN1_01 ,  TTTTGAG_MIR373 ,  CACGTG_MYC_Q2 ,  ZF5_01 ,  AP2GAMMA_01 ,  ARNT_02 ,  SREBP1_Q6 ,  AP2ALPHA_01 ,  GGTGAAG_MIR412 ,  GCCATNTTG_YY1_Q6 ,  WTGAAAT_UNKNOWN ,  AGCATTA_MIR155 ,  MYCMAX_02 ,  ATCATGA_MIR433 ,  CACCCBINDINGFACTOR_Q6 ,  GCACCTT_MIR18A_MIR18B ,  YY1_Q6 ,  NFY_Q6_01 ,  CAGGTG_E12_Q6 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  AREB6_01 ,  NFY_01 ,  HIF1_Q5 ,  ACTGCAG_MIR173P ,  RNGTGGGC_UNKNOWN ,  USF_Q6_01 ,  TTGTTT_FOXO4_01 ,  WTTGKCTG_UNKNOWN ,  CP2_02 ,  SREBP_Q3 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CCCNNNNNNAAGWT_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  CAGCTG_AP4_Q5 ,  CACBINDINGPROTEIN_Q6 ,  AACTTT_UNKNOWN ,  TCF1P_Q6 ,  CACTTTG_MIR520G_MIR520H ,  GGGTGGRR_PAX4_03 ,  ACACTGG_MIR199A_MIR199B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

14q23.2

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