QuickView for Hsd17b3 (gene)
- Gene Symbol:
- HSD17B3
Homo sapiens - Full name:
- hydroxysteroid 17-beta dehydrogenase 3
- Synonyms:
- EDH17B3, SDR12C2, testosterone 17-beta-dehydrogenase 3, 17-beta-HSD 3, 17-beta-HSD3, 17-beta-hydroxysteroid dehydrogenase type 3, hydroxysteroid dehydrogenase 3, short chain dehydrogenase/reductase family 12C member 2, testicular 17-beta-hydroxysteroid dehydrogenase
- Genomic Location:
- Chr 9: 98037410-98104255
- Description:
-
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
9q22.32
GO Molecular Function
oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | testosterone dehydrogenase (NAD+) activity | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | catalytic activity | testosterone 17-beta-dehydrogenase (NADP+) activity | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | oxidoreductase activity
GO Biological Process
oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | developmental process involved in reproduction | cellular process | reproductive system development | testosterone dehydrogenase (NAD+) activity | organic cyclic compound metabolic process | steroid biosynthetic process | androgen biosynthetic process | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | reproduction | androgen metabolic process | cellular biosynthetic process | organic hydroxy compound metabolic process | system development | reproductive process | multicellular organism development | hormone biosynthetic process | lipid metabolic process | regulation of hormone levels | testosterone 17-beta-dehydrogenase (NADP+) activity | small molecule metabolic process | cellular ketone metabolic process | biosynthetic process | lipid biosynthetic process | testosterone biosynthetic process | genitalia development | male sex differentiation | anatomical structure development | metabolic process | oxidation-reduction process | male genitalia development | organic substance metabolic process | animal organ development | steroid metabolic process | hormone metabolic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | reproductive structure development | developmental process | cellular metabolic process | sex differentiation | oxidoreductase activity | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane
