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QuickView for Hsd3b1 (gene)


Gene Symbol:
HSD3B1 Homo sapiens Homo sapiens
Full name:
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Synonyms:
3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, 3-beta-HSD I, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, delta-5-3-ketosteroid isomerase, progesterone reductase, short chain dehydrogenase/reductase family 11E, member 1, steroid Delta-isomerase, trophoblast antigen FDO161G
Genomic Location:
Chr 1: 119851349-119859204
Description:
The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Cytogenetic Map:
chr 1
1p12


Transcripts Names
NM_000862
NM_001328615
Protein Names
Q14545
Q8IV65
P14060
A8K691



GO Molecular Function

oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | intramolecular oxidoreductase activity, transposing C=C bonds | 3-beta-hydroxy-delta5-steroid dehydrogenase activity | isomerase activity | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | catalytic activity | intramolecular oxidoreductase activity | cholesterol dehydrogenase activity | steroid delta-isomerase activity | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | oxidoreductase activity

GO Biological Process

brain development | oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | hippocampus development | response to hormone | 3-beta-hydroxy-delta5-steroid dehydrogenase activity | nervous system development | estrogen biosynthetic process | estrogen metabolic process | cellular process | response to corticosterone | organic cyclic compound metabolic process | steroid biosynthetic process | head development | response to stimulus | androgen biosynthetic process | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | response to alcohol | androgen metabolic process | cellular biosynthetic process | system development | multicellular organism development | hormone biosynthetic process | lipid metabolic process | regulation of hormone levels | telencephalon development | response to ketone | response to lipid | response to corticosteroid | biosynthetic process | lipid biosynthetic process | mineralocorticoid biosynthetic process | limbic system development | response to organic substance | anatomical structure development | metabolic process | response to mineralocorticoid | cholesterol dehydrogenase activity | oxidation-reduction process | organic substance metabolic process | animal organ development | forebrain development | pallium development | C21-steroid hormone metabolic process | steroid metabolic process | glucocorticoid metabolic process | response to organic cyclic compound | hormone metabolic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | developmental process | glucocorticoid biosynthetic process | central nervous system development | cellular metabolic process | oxidoreductase activity | response to steroid hormone | response to glucocorticoid | multicellular organismal process

GO Cellular Component

integral component of membrane | mitochondrial intermembrane space | organelle inner membrane | intracellular membrane-bounded organelle | mitochondrial inner membrane | organelle membrane | cell | smooth endoplasmic reticulum | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | mitochondrion | membrane-bounded organelle | organelle | mitochondrial envelope | membrane-enclosed lumen | smooth endoplasmic reticulum membrane | mitochondrial membrane | intracellular | membrane