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QuickView for Hydroxypropyl cellulose (compound)

Summary
General Info

PubChem Substance

Name:	hydroxypropylcellulose
PubChem Substance ID:	204512
Synonyms:	78214-41-2; HPC-L; Cellulose hydroxypropyl ether; 150873-09-9; 9076-24-8; Hydroxypropyl cellulose; Lacrisert; 2-Hydroxypropyl cellulose; Hydroxypropyl ether of cellulose; Oxypropylated cellulose. show more » 78214-41-2; HPC-L; Cellulose hydroxypropyl ether; 150873-09-9; 9076-24-8; Hydroxypropyl cellulose; Lacrisert; 2-Hydroxypropyl cellulose; Hydroxypropyl ether of cellulose; Oxypropylated cellulose; 65742-73-6; Hydroxypropylcellulose; PM 50 (polymer); 173523-78-9; 193561-69-2; Klucel; 210920-15-3; CELLULOSE, 2-HYDROXYPROPYL ETHER; 192006-47-6; PM 50; Hyprolosum; 9004-64-2; L-Hpc; Hydroxypropylcellulose of low substitution show less «

DrugBank

Identification

Name:	hydroxypropylcellulose
Name (isomeric):	DB00840
Drug Type:	small molecule
Synonyms:	Hydroxypropylmethylcellulose phthalate; Hypromellose phthtalate
Brand:	Lacrisert
Category:	Artificial Tears, Ophthalmic Protectant
CAS number:	9004-64-2

Pharmacology

Indication:	Used to relieve dryness and irritation caused by reduced tear flow that occurs in certain eye diseases (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes.
Pharmacology:	Hydroxypropyl cellulose (cellulose, 2-hydroxypropyl ether) is a derivative of cellulose with both water solubility and organic solubility. Hydroxypropyl cellulose acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. Hydroxypropyl cellulose also ac... show more » Hydroxypropyl cellulose (cellulose, 2-hydroxypropyl ether) is a derivative of cellulose with both water solubility and organic solubility. Hydroxypropyl cellulose acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. Hydroxypropyl cellulose also acts to lubricate and protect the eye. Hydroxypropyl cellulose usually reduces the signs and symptoms resulting from moderate to severe dry eye syndromes, such as conjunctival hyperemia, corneal and conjunctival staining with rose bengal, exudation, itching, burning, foreign body sensation, smarting, photophobia, dryness and blurred or cloudy vision. Progressive visual deterioration which occurs in some patients may be retarded, halted, or sometimes reversed. show less «
Mechanism of Action:	Hydroxypropyl cellulose is a derivative of cellulose that is soluble in both water and organic solvents. It is particularly good at trapping water and producing a film that serves as a barrier to water loss. Hydroxypropyl cellulose possesses good surface activity but does not gel as it forms open helical coils. In general Hydroxypropyl cellulose is... show more » Hydroxypropyl cellulose is a derivative of cellulose that is soluble in both water and organic solvents. It is particularly good at trapping water and producing a film that serves as a barrier to water loss. Hydroxypropyl cellulose possesses good surface activity but does not gel as it forms open helical coils. In general Hydroxypropyl cellulose is a water-soluble thickener, emulsifier and film-former often used in tablet coating. show less «
Absorption:	Studies conducted in rats fed 14 C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces.
Protein binding:	None
Biotransformation:	Hydroxypropyl cellulose is a physiologically inert substance. In a study of rats fed hydroxypropyl cellulose or unmodified cellulose at levels up to 5% of their diet, it was found that the two were biologically equivalent in that neither was metabolized.
Route of elimination:	Studies conducted in rats fed 14C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces.
Toxicity:	LD₅₀=10200 mg/kg (oral, rat)
Affected organisms:	Humans and other mammals