QuickView for ICA512 (gene)

Gene Symbol:

PTPRN Homo sapiens

Full name:

protein tyrosine phosphatase, receptor type N

Synonyms:

IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N, receptor-type tyrosine-protein phosphatase-like N, ICA 512, PTP IA-2, insulinoma-associated tyrosine-phosphatase-like protein, islet cell antigen 2, islet cell antigen 512, islet cell autoantigen 3, protein tyrosine phosphatase-like N

Genomic Location:

Chr 2: 219862589-219882387

Description:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a si...

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  MZF1_01 ,  RYTTCCTG_ETS2_B ,  TGANNYRGCA_TCF11MAFG_01 ,  TGTGTGA_MIR377 ,  AP1_Q6 ,  NRSF_01 ,  GTGTGAG_MIR342 ,  CEBPDELTA_Q6 ,  NFE2_01 ,  AP1_01 ,  AP1FJ_Q2 ,  BACH2_01 ,  CAGNWMCNNNGAC_UNKNOWN ,  TGCTGAY_UNKNOWN ,  AP1_Q2_01 ,  NERF_Q2 ,  AP1_Q4 ,  OCT1_02 ,  CETS1P54_01 ,  ELK1_01 ,  AP1_Q2 ,  PAX4_03 ,  AP1_Q4_01 ,  GGGTGGRR_PAX4_03 ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-203

Cytogenetic Map:

2q35

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