QuickView for ICAM1 (gene)
- Gene Symbol:
- ICAM1
Homo sapiens - Full name:
- intercellular adhesion molecule 1
- Synonyms:
- BB2, CD54, P3.58, intercellular adhesion molecule 1, ICAM-1, cell surface glycoprotein P3.58, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, major group rhinovirus receptor
- Genomic Location:
- Chr 19: 10242779-10258291
- Description:
-
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
19p13.2
GO Molecular Function
transmembrane signaling receptor activity | protein-containing complex binding | signaling receptor binding | signaling receptor activity | integrin binding | cell adhesion molecule binding | protein binding | virus receptor activity
GO Biological Process
response to extracellular stimulus | regulation of ERK1 and ERK2 cascade | regulation of supramolecular fiber organization | adaptive immune response | regulation of blood vessel diameter | response to radiation | cellular response to decreased oxygen levels | positive regulation of locomotion | positive regulation of leukocyte adhesion to vascular endothelial cell | response to nutrient levels | positive regulation of blood circulation | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | extracellular structure organization | response to cytokine | response to interleukin-1 | cellular response to glucose stimulus | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | antigen processing and presentation | response to lipopolysaccharide | developmental process involved in reproduction | ovarian follicle development | endothelial cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | gonad development | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | female gonad development | T cell antigen processing and presentation | regulation of immune system process | response to hormone | regulation of nitric oxide biosynthetic process | regulation of cell shape | negative regulation of cellular process | response to dexamethasone | response to metal ion | cellular response to tumor necrosis factor | cell differentiation | endothelial cell differentiation | defense response | cellular response to extracellular stimulus | response to drug | cellular chemical homeostasis | regulation of leukocyte mediated cytotoxicity | glucose homeostasis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of cellular component movement | regulation of actin polymerization or depolymerization | response to antibiotic | sensory perception of mechanical stimulus | virion attachment to host cell | positive regulation of GTPase activity | positive regulation of cellular biosynthetic process | cellular process | positive regulation of actin filament polymerization | regulation of cell motility | localization | cellular homeostasis | T cell extravasation | negative regulation of signaling | positive regulation of reactive oxygen species metabolic process | reproductive system development | negative regulation of apoptotic process | response to hypoxia | Sertoli cell differentiation | membrane docking | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | response to peptide hormone | tissue development | interspecies interaction between organisms | positive regulation of vasoconstriction | negative regulation of apoptotic signaling pathway | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | interferon-gamma-mediated signaling pathway | regulation of protein complex assembly | cellular response to molecule of bacterial origin | regulation of cellular extravasation | positive regulation of cellular protein metabolic process | epithelium development | cellular response to organonitrogen compound | cellular component organization | entry into host cell | viral life cycle | T cell activation | cellular response to interferon-gamma | regulation of actin filament length | development of primary sexual characteristics | response to stimulus | negative regulation of epithelial cell apoptotic process | regulation of peptidyl-tyrosine phosphorylation | positive regulation of nitric oxide metabolic process | positive regulation of immune system process | positive regulation of protein metabolic process | cell adhesion mediated by integrin | regulation of blood vessel size | cellular response to xenobiotic stimulus | cellular response to hypoxia | response to stress | leukocyte activation involved in immune response | regulation of blood circulation | response to peptide | positive regulation of cell-cell adhesion | epithelial cell development | response to glucose | inflammatory response to antigenic stimulus | development of primary female sexual characteristics | reproduction | response to alcohol | response to molecule of bacterial origin | extracellular matrix organization | negative regulation of transport | cellular response to organic cyclic compound | blood circulation | regulation of cellular component size | regulation of cell adhesion | response to ethanol | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | leukocyte migration | regulation of nucleic acid-templated transcription | regulation of neurotransmitter levels | locomotion | response to nitrogen compound | cellular response to interleukin-6 | cellular response to hormone stimulus | positive regulation of reactive oxygen species biosynthetic process | regulation of cell projection assembly | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | cellular response to nutrient levels | response to oxygen levels | reproductive process | regulation of signal transduction | positive regulation of organelle organization | endothelium development | regulation of actin cytoskeleton organization | multicellular organism development | cell migration | cellular glucose homeostasis | regulation of MAPK cascade | response to amino acid | regulation of actin filament organization | leukocyte mediated immunity | regulation of catalytic activity | regulation of phosphorylation | adhesion of symbiont to host | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | viral entry into host cell | response to ketone | cellular response to stress | response to lipid | nervous system process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | establishment of endothelial barrier | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of cell migration | lymphocyte migration | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | response to corticosteroid | regulation of cellular component movement | regulation of endothelial cell apoptotic process | cellular response to alkaloid | positive regulation of hydrolase activity | negative regulation of extrinsic apoptotic signaling pathway | positive regulation of cell migration | cellular response to cytokine stimulus | receptor-mediated virion attachment to host cell | regulation of cellular protein metabolic process | cellular response to glucocorticoid stimulus | T cell activation involved in immune response | negative regulation of ion transport | response to toxic substance | regulation of GTPase activity | regulation of apoptotic signaling pathway | response to xenobiotic stimulus | regulation of epithelial cell apoptotic process | cellular response to corticosteroid stimulus | regulation of leukocyte migration | positive regulation of cellular extravasation | cellular response to drug | response to bacterium | cell communication | response to sulfur dioxide | regulation of cellular metabolic process | regulation of actin filament polymerization | inflammatory response | T cell mediated immunity | negative regulation of calcium ion transport | cell activation involved in immune response | sensory perception of sound | adhesion of symbiont to host cell | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | response to monosaccharide | regulation of protein phosphorylation | establishment of endothelial intestinal barrier | regulation of locomotion | regulation of RNA metabolic process | regulation of tube size | viral process | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | cell aging | lymphocyte activation | positive regulation of molecular function | acute inflammatory response to antigenic stimulus | development of primary male sexual characteristics | positive regulation of protein modification process | response to organic substance | male sex differentiation | response to antineoplastic agent | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | Sertoli cell development | response to insulin | anatomical structure development | response to amine | cell surface receptor signaling pathway | regulation of vasoconstriction | leukocyte cell-cell adhesion | positive regulation of supramolecular fiber organization | regulation of RNA biosynthetic process | negative regulation of programmed cell death | male gonad development | regulation of tube diameter | cellular response to carbohydrate stimulus | chemical homeostasis | cell adhesion | regulation of ruffle assembly | immune response | positive regulation of cellular component biogenesis | response to copper ion | virus receptor activity | animal organ development | membrane to membrane docking | positive regulation of NF-kappaB transcription factor activity | positive regulation of leukocyte migration | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | response to alkaloid | cellular response to steroid hormone stimulus | cell-cell adhesion | response to interferon-gamma | response to gonadotropin | cell activation | positive regulation of MAPK cascade | cellular response to dexamethasone stimulus | regulation of reactive oxygen species biosynthetic process | sensory perception | establishment of Sertoli cell barrier | regulation of cell communication | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | cellular response to leukemia inhibitory factor | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | positive regulation of phosphorylation | response to biotic stimulus | reproductive structure development | regulation of developmental process | regulation of ion transport | developmental process | cellular response to interleukin-1 | regulation of calcium ion transport | cellular extravasation | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of cell-cell adhesion | innate immune response | positive regulation of protein polymerization | response to organonitrogen compound | epithelial cell differentiation | T cell migration | positive regulation of nitric oxide biosynthetic process | cell-cell adhesion via plasma-membrane adhesion molecules | positive regulation of metabolic process | regulation of actin filament-based process | response to amphetamine | regulation of cell projection organization | acute inflammatory response | immune system process | female sex differentiation | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | sex differentiation | positive regulation of cell motility | response to carbohydrate | response to steroid hormone | response to interleukin-6 | negative regulation of cell death | aging | carbohydrate homeostasis | positive regulation of leukocyte cell-cell adhesion | regulation of cellular component organization | response to ionizing radiation | regulation of cytoskeleton organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endothelial cell apoptotic process | response to glucocorticoid | cellular response to lipopolysaccharide | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | immunological synapse | extracellular matrix | adherens junction | focal adhesion | cell | intrinsic component of membrane | external side of plasma membrane | collagen-containing extracellular matrix | cell-substrate junction | membrane microdomain | plasma membrane | membrane raft | vesicle | extracellular exosome | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | cell-substrate adherens junction | cell surface | cell junction | membrane | intrinsic component of plasma membrane
