QuickView for IFI16 (gene)

Gene Symbol:

IFI16 Homo sapiens

Full name:

interferon gamma inducible protein 16

Synonyms:

IFNGIP1, PYHIN2, gamma-interferon-inducible protein 16, interferon-gamma induced protein IFI 16, interferon-inducible myeloid differentiation transcriptional activator

Genomic Location:

Chr 1: 157246306-157291569

Description:

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and...

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This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TAATTA_CHX10_01

Cytogenetic Map:

1q23.1

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