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QuickView for IFN-gamma (gene)


Gene Symbol:
IFNG Homo sapiens Homo sapiens
Full name:
interferon gamma
Synonyms:
IFG, IFI, interferon gamma, IFN-gamma, immune interferon
Genomic Location:
Chr 12: 66834817-66839788
Description:
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 12
12q15


Transcripts Names
NM_000619
Protein Names
Q53ZV4
P01579
B5BU88



GO Molecular Function

signaling receptor binding | cytokine receptor binding | molecular function regulator | interferon-gamma receptor binding | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity

GO Biological Process

positive regulation of immune response | positive regulation of exosomal secretion | positive regulation of cell killing | adaptive immune response | positive regulation of hormone biosynthetic process | positive regulation of locomotion | regulation of dephosphorylation | regulation of intracellular protein transport | response to virus | response to cytokine | positive regulation of cellular component organization | regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation | regulation of cellular localization | positive regulation of apoptotic process | regulation of localization | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | defense response to other organism | establishment of localization | regulation of autophagy | regulation of immune system process | regulation of nitric oxide biosynthetic process | negative regulation of cellular process | positive regulation of developmental process | regulation of phosphatase activity | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | regulation of protein localization to membrane | regulation of protein import | regulation of T cell differentiation | regulation of vitamin metabolic process | defense response | positive regulation of protein catabolic process | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | regulation of peptide hormone secretion | intracellular transport | regulation of response to interferon-gamma | positive regulation of T cell differentiation | positive regulation of dephosphorylation | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | localization | extrinsic apoptotic signaling pathway | protein transport | positive regulation of immune effector process | positive regulation of peptidyl-serine phosphorylation | positive regulation of reactive oxygen species metabolic process | positive regulation of killing of cells of other organism | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | macromolecule localization | regulation of response to cytokine stimulus | positive regulation of oxidoreductase activity | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | positive regulation of muscle cell apoptotic process | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of binding | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | interferon-gamma-mediated signaling pathway | regulation of protein complex assembly | protein import into nucleus | regulation of interferon-gamma-mediated signaling pathway | positive regulation of cellular protein metabolic process | positive regulation of epithelial cell migration | cellular response to interferon-gamma | regulation of peptide secretion | response to stimulus | regulation of regulatory T cell differentiation | regulation of cellular protein localization | positive regulation of osteoclast differentiation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of nitric oxide metabolic process | regulation of insulin secretion | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of smooth muscle cell apoptotic process | regulation of CD4-positive, alpha-beta T cell activation | positive regulation of peptidyl-serine phosphorylation of STAT protein | response to stress | intracellular protein transport | positive regulation of JAK-STAT cascade | positive regulation of cellular protein localization | positive regulation of membrane protein ectodomain proteolysis | regulation of cell proliferation | positive regulation of lipid biosynthetic process | positive regulation of cell-cell adhesion | protein localization to nucleus | regulation of epithelial cell differentiation | positive regulation of protein deacetylation | programmed cell death | positive regulation of phosphatase activity | regulation of transcription regulatory region DNA binding | positive regulation of cell activation | cellular localization | positive regulation of proteolysis | positive regulation of T cell activation | regulation of DNA binding | regulation of calcidiol 1-monooxygenase activity | regulation of protein transport | positive regulation of vitamin D biosynthetic process | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | regulation of peptide transport | regulation of cell adhesion | regulation of steroid biosynthetic process | response to interleukin-12 | interleukin-12-mediated signaling pathway | regulation of steroid metabolic process | regulation of intracellular transport | molecular function regulator | regulation of lymphocyte differentiation | regulation of nucleic acid-templated transcription | positive regulation of exocytosis | regulation of neurotransmitter levels | positive regulation of monooxygenase activity | apoptotic process | positive regulation of reactive oxygen species biosynthetic process | response to external biotic stimulus | regulation of signal transduction | regulation of exosomal secretion | positive regulation of lymphocyte differentiation | positive regulation of tumor necrosis factor (ligand) superfamily member 11 production | protein import into nucleus, translocation | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of killing of cells of other organism | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell activation | positive regulation of protein localization to plasma membrane | positive regulation of alpha-beta T cell differentiation | regulation of gene expression | positive regulation of secretion | organic substance transport | cell cycle | positive regulation of intracellular protein transport | negative regulation of cytokine production | regulation of protein import into nucleus, translocation | positive regulation of cellular metabolic process | defense response to virus | positive regulation of protein phosphorylation | regulation of lymphocyte activation | negative regulation of smooth muscle cell proliferation | positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of STAT cascade | positive regulation of interleukin-12 production | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation | negative regulation of interleukin-17 production | regulation of smooth muscle cell apoptotic process | protein localization to organelle | positive regulation of hydrolase activity | import into nucleus | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | positive regulation of steroid metabolic process | positive regulation of cell migration | cellular response to cytokine stimulus | positive regulation of interleukin-23 production | positive regulation of protein localization to nucleus | regulation of hormone metabolic process | regulation of cellular protein metabolic process | regulation of interleukin-23 production | protein import | regulation of muscle cell apoptotic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of core promoter binding | positive regulation of protein localization to membrane | regulation of protein deacetylation | positive regulation of tyrosine phosphorylation of STAT protein | regulation of alpha-beta T cell differentiation | humoral immune response | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | regulation of lipid biosynthetic process | apoptotic signaling pathway | negative regulation of epithelial cell differentiation | positive regulation of molecular function | regulation of nucleocytoplasmic transport | regulation of signaling receptor activity | receptor regulator activity | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of innate immune response | regulation of protein import into nucleus | regulation of hemopoiesis | cell cycle arrest | regulation of JAK-STAT cascade | regulation of kinase activity | positive regulation of steroid biosynthetic process | regulation of intracellular signal transduction | regulation of exocytosis | establishment of protein localization to organelle | positive regulation of calcidiol 1-monooxygenase activity | cell surface receptor signaling pathway | regulation of protein catabolic process | regulation of protein localization to plasma membrane | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of transcription, DNA-templated | cellular protein localization | amide transport | regulation of vesicle-mediated transport | regulation of secretion | positive regulation of cell death | receptor ligand activity | immune response | positive regulation of cellular component biogenesis | cytokine activity | nuclear transport | cell death | positive regulation of core promoter binding | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of cell activation | regulation of protein secretion | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of binding | positive regulation of autophagy | establishment of protein localization | response to interferon-gamma | positive regulation of cytokine production | regulation of protein ADP-ribosylation | positive regulation of intracellular transport | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | regulation of peptidyl-serine phosphorylation | negative regulation of cell cycle | regulation of epithelial cell migration | regulation of osteoclast differentiation | positive regulation of protein import into nucleus, translocation | regulation of cell communication | signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | regulation of peptidyl-serine phosphorylation of STAT protein | positive regulation of DNA binding | positive regulation of CD4-positive, alpha-beta T cell differentiation | protein localization | positive regulation of phosphorylation | regulation of cytokine production | positive regulation of regulatory T cell differentiation | cellular macromolecule localization | positive regulation of protein import into nucleus | response to biotic stimulus | nucleocytoplasmic transport | regulation of developmental process | positive regulation of alpha-beta T cell activation | positive regulation of protein import | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response | negative regulation of transcription by RNA polymerase II | regulation of transport | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | innate immune response | positive regulation of fructose 1,6-bisphosphate metabolic process | positive regulation of nitric oxide biosynthetic process | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | positive regulation of myeloid leukocyte differentiation | immune system process | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | positive regulation of CD4-positive, alpha-beta T cell activation | positive regulation of nucleocytoplasmic transport | positive regulation of leukocyte cell-cell adhesion | negative regulation of cell differentiation | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of hormone biosynthetic process | positive regulation of transcription regulatory region DNA binding | regulation of phosphorus metabolic process

GO Cellular Component

cell | extracellular region | extracellular space | intracellular