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QuickView for IGF1R (gene)


Gene Symbol:
IGF1R Homo sapiens Homo sapiens
Full name:
insulin like growth factor 1 receptor
Synonyms:
CD221, IGFIR, IGFR, JTK13, insulin-like growth factor 1 receptor, IGF-I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2
Genomic Location:
Chr 15: 97010284-97325282
Description:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agen...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 15
15q26.3





GO Molecular Function

insulin-like growth factor-activated receptor activity | phosphatidylinositol 3-kinase binding | transmembrane receptor protein tyrosine kinase activity | peptide binding | peptide hormone binding | transmembrane signaling receptor activity | protein-containing complex binding | ribonucleotide binding | insulin binding | nucleotide binding | insulin-like growth factor I binding | signaling receptor binding | carbohydrate derivative binding | growth factor binding | catalytic activity | ATP binding | insulin-like growth factor binding | anion binding | adenyl nucleotide binding | amide binding | signaling receptor activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | hormone binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | insulin receptor binding | transferase activity, transferring phosphorus-containing groups | insulin-activated receptor activity | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | insulin receptor substrate binding | heterocyclic compound binding | small molecule binding | protein-hormone receptor activity

GO Biological Process

insulin-like growth factor-activated receptor activity | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | positive regulation of locomotion | negative regulation of MAPK cascade | positive regulation of cellular component organization | intracellular signal transduction | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | response to hormone | negative regulation of cellular process | negative regulation of kinase activity | regulation of MAP kinase activity | cell differentiation | negative regulation of protein phosphorylation | glucose homeostasis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | positive regulation of cellular component movement | cellular process | regulation of cell motility | negative regulation of signaling | dendritic spine organization | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | peptidyl-tyrosine autophosphorylation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of protein complex disassembly | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | insulin-like growth factor receptor signaling pathway | cellular component organization | response to stimulus | positive regulation of cold-induced thermogenesis | positive regulation of protein metabolic process | negative regulation of protein kinase activity | regulation of cell proliferation | response to peptide | phosphatidylinositol-mediated signaling | negative regulation of metabolic process | cellular component assembly | protein modification process | macromolecule modification | regulation of cellular response to stress | response to nitrogen compound | cellular response to hormone stimulus | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | cellular response to peptide hormone stimulus | regulation of MAPK cascade | phosphorus metabolic process | protein complex oligomerization | cellular response to insulin stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of protein complex disassembly | cellular response to peptide | insulin receptor signaling pathway | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | amyloid-beta clearance | positive regulation of intracellular signal transduction | regulation of cellular component movement | synapse organization | positive regulation of cell migration | regulation of cellular protein metabolic process | phosphorylation | inositol lipid-mediated signaling | protein tetramerization | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | cellular response to amyloid-beta | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | inactivation of MAPKK activity | regulation of protein phosphorylation | regulation of locomotion | protein tyrosine kinase activity | protein-containing complex assembly | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | phosphatidylinositol 3-kinase signaling | response to insulin | cell surface receptor signaling pathway | cellular component maintenance | cell projection organization | metabolic process | insulin-activated receptor activity | negative regulation of programmed cell death | chemical homeostasis | immune response | protein kinase activity | organic substance metabolic process | negative regulation of cellular protein metabolic process | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | regulation of JNK cascade | positive regulation of MAPK cascade | negative regulation of protein metabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | response to amyloid-beta | dendritic spine maintenance | positive regulation of phosphorylation | cellular protein metabolic process | kinase activity | developmental process | cellular protein modification process | response to organonitrogen compound | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | carbohydrate homeostasis | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | catalytic complex | neuron projection | protein kinase complex | cell | plasma membrane protein complex | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | protein-containing complex | cell projection | plasma membrane | transferase complex | alphav-beta3 integrin-IGF-1-IGF1R complex | integral component of plasma membrane | membrane-bounded organelle | organelle | insulin receptor complex | cell periphery | axon | intracellular | membrane | intrinsic component of plasma membrane