QuickView for IKBKB (gene)

Gene Symbol:

IKBKB Homo sapiens

Full name:

inhibitor of nuclear factor kappa B kinase subunit beta

Synonyms:

IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, nuclear factor NF-kappa-B inhibitor kinase beta

Genomic Location:

Chr 8: 42247986-42309122

Description:

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  ETS_Q4 ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  RYTTCCTG_ETS2_B ,  TEL2_Q6 ,  ATF4_Q2 ,  CREB_Q4 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  CREBP1_Q2 ,  GTGACGY_E4F1_Q6 ,  ATF_01 ,  ETS2_B ,  ATF3_Q6 ,  GCGNNANTTCC_UNKNOWN ,  NERF_Q2 ,  E4F1_Q6 ,  MGGAAGTG_GABP_B ,  CTTTAAR_UNKNOWN ,  ATF1_Q6 ,  CREB_Q2 ,  TGACGTCA_ATF3_Q6 ,  P300_01 ,  ETS1_B ,  ELF1_Q6 ,  CREB_Q2_01 ,  CREB_01 ,  ACACTGG_MIR199A_MIR199B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-199

miRNA binding sites
(Source: miRecords):

hsa-miR-199a Targeted Genes

Cytogenetic Map:

8p11.21

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