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QuickView for IL-12B (gene)


Gene Symbol:
IL12B Homo sapiens Homo sapiens
Full name:
interleukin 12B
Synonyms:
CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2, interleukin-12 subunit beta, CLMF p40, IL-12 subunit p40, IL12, subunit p40, NK cell stimulatory factor chain 2, cytotoxic lymphocyte maturation factor 40 kDa subunit, interleukin 12, p40, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), interleukin-12 beta chain, natural killer cell stimulatory factor, 40 kD subunit
Genomic Location:
Chr 5: 158674369-158690059
Description:
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated m...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Gallus gallus Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5q33.3


Transcripts Names
NM_002187
Protein Names
P29460



GO Molecular Function

cytokine binding | transmembrane signaling receptor activity | signaling receptor binding | cytokine receptor binding | molecular function regulator | interleukin-12 binding | interleukin-12 alpha subunit binding | signaling receptor activity | identical protein binding | protein heterodimerization activity | cytokine receptor activity | protein binding | protein homodimerization activity | receptor regulator activity | protein dimerization activity | growth factor activity | receptor ligand activity | cytokine activity | interleukin-23 receptor binding | growth factor receptor binding | interleukin-12 receptor binding

GO Biological Process

positive regulation of immune response | positive regulation of cell killing | regulation of T cell mediated immunity | adaptive immune response | response to radiation | positive regulation of macromolecule biosynthetic process | response to virus | negative regulation of immune system process | CD4-positive, alpha-beta T cell differentiation | response to cytokine | cell motility | CD4-positive, alpha-beta T cell activation | response to lipopolysaccharide | positive regulation of apoptotic process | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | defense response to other organism | regulation of immune system process | regulation of T-helper 17 type immune response | negative regulation of cellular process | positive regulation of developmental process | positive regulation of lymphocyte activation | cell differentiation | regulation of T cell differentiation | regulation of T cell mediated cytotoxicity | negative regulation of growth of symbiont involved in interaction with host | defense response | regulation of leukocyte mediated cytotoxicity | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | defense response to Gram-negative bacterium | positive regulation of T cell differentiation | positive regulation of cellular biosynthetic process | cellular process | negative regulation of inflammatory response | lymphocyte differentiation | regulation of cytokine biosynthetic process | localization | positive regulation of immune effector process | positive regulation of memory T cell differentiation | positive regulation of adaptive immune response | T-helper 1 type immune response | positive regulation of T-helper 17 cell differentiation | immune system development | positive regulation of protein kinase activity | positive regulation of defense response to virus by host | regulation of defense response to virus | regulation of cell cycle | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | positive regulation of natural killer cell proliferation | positive regulation of muscle cell apoptotic process | positive regulation of interferon-gamma biosynthetic process | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | positive regulation of granulocyte macrophage colony-stimulating factor production | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | positive regulation of activated T cell proliferation | T cell differentiation involved in immune response | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | positive regulation of cellular protein metabolic process | regulation of natural killer cell activation | T cell cytokine production | T cell activation | cellular response to interferon-gamma | positive regulation of natural killer cell mediated immunity | positive regulation of tumor necrosis factor production | positive regulation of interleukin-17 production | response to UV | response to stimulus | positive regulation of NIK/NF-kappaB signaling | positive regulation of innate immune response | alpha-beta T cell activation involved in immune response | positive regulation of osteoclast differentiation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of smooth muscle cell apoptotic process | regulation of CD4-positive, alpha-beta T cell activation | response to stress | positive regulation of JAK-STAT cascade | leukocyte activation involved in immune response | positive regulation of lymphocyte proliferation | regulation of activation of Janus kinase activity | regulation of cell proliferation | positive regulation of cell-cell adhesion | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | reproduction | positive regulation of natural killer cell activation | response to molecule of bacterial origin | positive regulation of T cell activation | positive regulation of T-helper 17 cell lineage commitment | hemopoiesis | regulation of cell adhesion | response to interleukin-12 | interleukin-12-mediated signaling pathway | molecular function regulator | regulation of lymphocyte differentiation | positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | T-helper cell differentiation | leukocyte differentiation | locomotion | response to light stimulus | positive regulation of mononuclear cell proliferation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of growth | multicellular organism development | cell migration | positive regulation of lymphocyte differentiation | positive regulation of inflammatory response | leukocyte mediated immunity | regulation of catalytic activity | regulation of phosphorylation | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell activation | positive regulation of alpha-beta T cell differentiation | regulation of activated T cell proliferation | response to lipid | nervous system process | cell cycle | interferon-gamma biosynthetic process | response to UV-B | negative regulation of cytokine production | positive regulation of cellular metabolic process | defense response to virus | positive regulation of protein phosphorylation | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | negative regulation of smooth muscle cell proliferation | CD4-positive, alpha-beta T cell cytokine production | regulation of nitrogen compound metabolic process | positive regulation of STAT cascade | positive regulation of interleukin-12 production | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | alpha-beta T cell differentiation | negative regulation of interleukin-17 production | regulation of smooth muscle cell apoptotic process | regulation of T-helper 17 cell differentiation | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | positive regulation of NK T cell activation | sensory perception of pain | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | negative regulation of immune response | T cell activation involved in immune response | cytokine production involved in immune response | regulation of tumor necrosis factor production | defense response to protozoan | cytokine receptor activity | response to bacterium | regulation of muscle cell apoptotic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of natural killer cell proliferation | positive regulation of NK T cell proliferation | positive regulation of tyrosine phosphorylation of STAT protein | regulation of alpha-beta T cell differentiation | T cell mediated immunity | cell activation involved in immune response | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | defense response to bacterium | positive regulation of cell proliferation | regulation of protein phosphorylation | lymphocyte activation | positive regulation of molecular function | cytokine production | T cell differentiation | regulation of signaling receptor activity | receptor regulator activity | protein metabolic process | positive regulation of T-helper cell differentiation | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of innate immune response | regulation of hemopoiesis | cell cycle arrest | regulation of JAK-STAT cascade | regulation of kinase activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | growth factor activity | metabolic process | negative regulation of growth of symbiont in host | regulation of adaptive immune response | positive regulation of leukocyte activation | regulation of tissue remodeling | positive regulation of cell death | receptor ligand activity | immune response | cytokine activity | organic substance metabolic process | interleukin-23-mediated signaling pathway | positive regulation of T-helper 1 type immune response | positive regulation of T cell mediated cytotoxicity | animal organ development | regulation of cell activation | positive regulation of programmed cell death | response to protozoan | positive regulation of kinase activity | alpha-beta T cell activation | regulation of phosphate metabolic process | positive regulation of natural killer cell mediated cytotoxicity | response to interferon-gamma | positive regulation of cytokine production | cell activation | positive regulation of T cell mediated immunity | regulation of natural killer cell mediated cytotoxicity | regulation of T-helper cell differentiation | negative regulation of cell cycle | sensory perception | regulation of osteoclast differentiation | regulation of cell communication | positive regulation of interleukin-10 production | natural killer cell activation | signaling | regulation of T cell proliferation | positive regulation of CD4-positive, alpha-beta T cell differentiation | positive regulation of phosphorylation | regulation of cytokine production | response to biotic stimulus | positive regulation of tissue remodeling | natural killer cell activation involved in immune response | regulation of developmental process | cytokine biosynthetic process | developmental process | positive regulation of alpha-beta T cell activation | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of leukocyte mediated cytotoxicity | innate immune response | positive regulation of T-helper 17 type immune response | regulation of defense response to virus by host | positive regulation of cell fate commitment | cytokine metabolic process | regulation of cell fate commitment | T-helper 1 cell cytokine production | positive regulation of metabolic process | regulation of interferon-gamma production | positive regulation of myeloid leukocyte differentiation | immune system process | regulation of natural killer cell mediated immunity | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | negative regulation of inflammatory response to antigenic stimulus | positive regulation of CD4-positive, alpha-beta T cell activation | regulation of inflammatory response | sexual reproduction | positive regulation of leukocyte cell-cell adhesion | positive regulation of immune response to tumor cell | regulation of memory T cell differentiation | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of activation of Janus kinase activity | interferon-gamma production | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | negative regulation of interleukin-10 production | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | late endosome | cytoplasmic vesicle | cell | interleukin-12 complex | external side of plasma membrane | cytoplasm | intracellular organelle | receptor complex | endoplasmic reticulum | interleukin-23 complex | protein-containing complex | endomembrane system | plasma membrane | late endosome lumen | vesicle | endoplasmic reticulum lumen | endosome | extracellular region | membrane-bounded organelle | endosome lumen | organelle | extracellular space | cell periphery | membrane-enclosed lumen | cytosol | intracellular vesicle | cell surface | intracellular | membrane