QuickView for IL-1B (gene)
- Gene Symbol:
- Il1b
Mus musculus - Full name:
- interleukin 1 beta
- Synonyms:
- IL-1beta, Il-1b, interleukin-1 beta, IL-1 beta
- Genomic Location:
- Chr 2: 129190315-129196856
- Description:
-
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1. The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response.
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Danio rerio , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
protein-containing complex binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | protein domain specific binding | integrin binding | cell adhesion molecule binding | protein binding | receptor regulator activity | interleukin-1 receptor binding | receptor ligand activity | cytokine activity | growth factor receptor binding
GO Biological Process
positive regulation of immune response | regulation of JUN kinase activity | response to extracellular stimulus | regulation of leukocyte chemotaxis | regulation of ERK1 and ERK2 cascade | regulation of T cell mediated immunity | negative regulation of phosphorylation | response to radiation | positive regulation of hormone biosynthetic process | regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell cycle process | negative regulation of cellular response to insulin stimulus | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to nutrient levels | negative regulation of MAPK cascade | response to ATP | response to cytokine | cellular response to glucose stimulus | positive regulation of cellular component organization | cell motility | regulation of neurogenesis | response to lipopolysaccharide | developmental process involved in reproduction | negative regulation of peptide secretion | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | regulation of localization | response to isoquinoline alkaloid | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | positive regulation of lipid catabolic process | response to immobilization stress | regulation of immune system process | response to hormone | lipid storage | regulation of nitric oxide biosynthetic process | regulation of immature T cell proliferation in thymus | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | regulation of MAP kinase activity | social behavior | response to dexamethasone | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | cell differentiation | regulation of T cell differentiation | regulation of vitamin metabolic process | defense response | nervous system development | positive regulation of protein catabolic process | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | neurogenesis | glucose homeostasis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | negative regulation of protein secretion | regulation of organelle organization | positive regulation of cellular component movement | regulation of peptide hormone secretion | generation of neurons | positive regulation of protein secretion | response to antibiotic | regulation of lipid transport | positive regulation of T cell differentiation | regulation of neuron death | response to organophosphorus | positive regulation of cellular biosynthetic process | cellular process | positive regulation of T cell differentiation in thymus | response to morphine | regulation of cytokine biosynthetic process | regulation of cell motility | localization | cellular homeostasis | extrinsic apoptotic signaling pathway | negative regulation of glutamate secretion | negative regulation of signaling | positive regulation of immune effector process | positive regulation of reactive oxygen species metabolic process | response to estradiol | positive regulation of adaptive immune response | positive regulation of epithelial to mesenchymal transition | positive regulation of heterotypic cell-cell adhesion | regulation of mitotic nuclear division | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | regulation of estradiol secretion | positive regulation of protein kinase activity | negative regulation of amino acid transport | macromolecule localization | regulation of chemotaxis | negative regulation of apoptotic process | negative regulation of secretion | response to hypoxia | positive regulation of oxidoreductase activity | regulation of defense response to virus | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | granulocyte chemotaxis | negative regulation of hormone secretion | response to inorganic substance | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | response to peptide hormone | regulation of cell differentiation | gamete generation | negative regulation of apoptotic signaling pathway | regulation of angiogenesis | positive regulation of interleukin-8 production | positive regulation of granulocyte macrophage colony-stimulating factor production | regulation of immune response | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | positive regulation of neutrophil migration | positive regulation of stress-activated MAPK cascade | regulation of cytosolic calcium ion concentration | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | positive regulation of cellular protein metabolic process | positive regulation of T cell cytokine production | MAPK cascade | calcium ion homeostasis | regulation of neutrophil chemotaxis | regulation of cell division | glycosaminoglycan biosynthetic process | response to stilbenoid | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | regulation of vasculature development | response to stimulus | negative regulation of protein transport | ovulation | female gamete generation | positive regulation of NIK/NF-kappaB signaling | cellular response to mechanical stimulus | neutrophil chemotaxis | positive regulation of nitric oxide metabolic process | regulation of insulin secretion | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | interleukin-1 beta production | leukocyte aggregation | response to stress | regulation of heterotypic cell-cell adhesion | positive regulation of chemokine biosynthetic process | negative regulation of protein kinase activity | positive regulation of lymphocyte proliferation | positive regulation of membrane protein ectodomain proteolysis | response to ozone | regulation of cell proliferation | positive regulation of lipid biosynthetic process | multicellular organismal homeostasis | negative regulation of glucose transmembrane transport | response to peptide | positive regulation of cell-cell adhesion | response to glucose | regulation of epithelial cell differentiation | inflammatory response to antigenic stimulus | programmed cell death | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | reproduction | positive regulation of vascular endothelial growth factor production | response to alcohol | positive regulation of cytokine secretion | response to temperature stimulus | positive regulation of proteolysis | response to molecule of bacterial origin | positive regulation of T cell activation | positive regulation of hormone secretion | negative regulation of transport | positive regulation of gliogenesis | cellular response to organic cyclic compound | regulation of calcidiol 1-monooxygenase activity | regulation of phagocytosis | carbohydrate derivative biosynthetic process | regulation of protein transport | response to vitamin D | positive regulation of vitamin D biosynthetic process | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | protein modification process | regulation of peptide transport | modulation of chemical synaptic transmission | regulation of cell adhesion | regulation of steroid biosynthetic process | cellular biosynthetic process | regulation of morphogenesis of a branching structure | macromolecule modification | regulation of steroid metabolic process | negative regulation of transmembrane transport | cell chemotaxis | activation of protein kinase activity | molecular function regulator | metal ion homeostasis | regulation of lymphocyte differentiation | response to ethanol | regulation of fever generation | leukocyte migration | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | monocyte aggregation | regulation of cellular response to stress | regulation of neurotransmitter levels | positive regulation of monooxygenase activity | locomotion | response to nitrogen compound | apoptotic process | protein kinase B signaling | regulation of interleukin-2 biosynthetic process | positive regulation of reactive oxygen species biosynthetic process | positive regulation of mononuclear cell proliferation | response to external biotic stimulus | system development | negative regulation of adiponectin secretion | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of secretion by cell | negative regulation of phosphate metabolic process | positive regulation of T-helper 1 cell cytokine production | positive regulation of icosanoid secretion | cellular response to antibiotic | multicellular organism development | negative regulation of catalytic activity | cell migration | positive regulation of lymphocyte differentiation | cellular glucose homeostasis | regulation of MAPK cascade | phosphorus metabolic process | response to purine-containing compound | positive regulation of inflammatory response | negative regulation of lipid catabolic process | learning or memory | response to fatty acid | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of granulocyte chemotaxis | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | hyaluronan metabolic process | wound healing | regulation of nitric-oxide synthase activity | regulation of acute inflammatory response | regulation of T cell activation | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of neuron differentiation | regulation of gene expression | positive regulation of chemotaxis | regulation of extrinsic apoptotic signaling pathway | positive regulation of secretion | response to ketone | response to lipid | nervous system process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular ion homeostasis | response to ammonium ion | positive regulation of p38MAPK cascade | positive regulation of heat generation | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of JNK cascade | positive regulation of interleukin-2 biosynthetic process | small molecule metabolic process | regulation of interleukin-6 biosynthetic process | negative regulation of insulin receptor signaling pathway | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | response to corticosteroid | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to nutrient | response to oxidative stress | positive regulation of cell differentiation | acute-phase response | regulation of T cell cytokine production | negative regulation of extrinsic apoptotic signaling pathway | cognition | hyaluronan biosynthetic process | positive regulation of steroid metabolic process | positive regulation of cell migration | cellular response to cytokine stimulus | biosynthetic process | regulation of hormone metabolic process | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | positive regulation of monocyte chemotactic protein-1 production | phosphorylation | negative regulation of ion transport | positive regulation of neuron death | interleukin-6 production | positive regulation of chemokine production | response to toxic substance | regulation of glutamate secretion | positive regulation of lipid localization | regulation of apoptotic signaling pathway | response to xenobiotic stimulus | programmed cell death involved in cell development | protein phosphorylation | response to gamma radiation | cation homeostasis | regulation of leukocyte migration | phosphate-containing compound metabolic process | cellular response to drug | response to bacterium | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | negative regulation of branching morphogenesis of a nerve | regulation of neuron apoptotic process | positive regulation of leukocyte chemotaxis | regulation of lipid catabolic process | regulation of establishment of endothelial barrier | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | inflammatory response | regulation of cytokine production involved in immune response | regulation of endocrine process | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | negative regulation of MAP kinase activity | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | positive regulation of myosin light chain kinase activity | positive regulation of transport | regulation of lipid biosynthetic process | cellular response to fatty acid | apoptotic signaling pathway | fever generation | regulation of mitotic cell cycle | carboxylic acid metabolic process | positive regulation of molecular function | regulation of cytokine secretion | multicellular organism reproduction | activation of MAPK activity | cytokine production | regulation of signaling receptor activity | receptor regulator activity | positive regulation of estradiol secretion | chronic inflammatory response | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of hemopoiesis | regulation of kinase activity | response to wounding | positive regulation of immature T cell proliferation | response to antineoplastic agent | response to mechanical stimulus | positive regulation of steroid biosynthetic process | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | anatomical structure development | positive regulation of calcidiol 1-monooxygenase activity | cell surface receptor signaling pathway | positive regulation of neurogenesis | regulation of neural precursor cell proliferation | leukocyte cell-cell adhesion | negative regulation of lipid metabolic process | metabolic process | lipid localization | positive regulation of cell development | regulation of neutrophil migration | regulation of protein catabolic process | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | positive regulation of cytokine production involved in immune response | positive regulation of neutrophil chemotaxis | cellular response to carbohydrate stimulus | positive regulation of glial cell differentiation | regulation of vesicle-mediated transport | chemical homeostasis | regulation of secretion | behavior | positive regulation of cell death | cell adhesion | receptor ligand activity | positive regulation of interleukin-6 production | immune response | cytokine activity | organic substance metabolic process | positive regulation of T-helper 1 type immune response | positive regulation of acute inflammatory response | cell death | response to vitamin | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of glucose transmembrane transport | positive regulation of ion transport | response to reactive oxygen species | negative regulation of neuron differentiation | regulation of insulin receptor signaling pathway | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | regulation of protein secretion | positive regulation of leukocyte migration | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of kinase activity | positive regulation of phagocytosis | response to heat | ion homeostasis | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | response to alkaloid | positive regulation of astrocyte differentiation | response to L-ascorbic acid | positive regulation of organic acid transport | cell-cell adhesion | positive regulation of cytokine production | regulation of JNK cascade | positive regulation of MAPK cascade | positive regulation of T cell mediated immunity | temperature homeostasis | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | memory | negative regulation of protein metabolic process | regulation of glial cell differentiation | positive regulation of fever generation | regulation of stress-activated MAPK cascade | regulation of cell communication | sequestering of triglyceride | regulation of gliogenesis | negative regulation of molecular function | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | response to organic cyclic compound | cell development | regulation of endocytosis | regulation of T cell proliferation | organic acid metabolic process | extrinsic apoptotic signaling pathway in absence of ligand | regulation of T cell differentiation in thymus | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | positive regulation of MAP kinase activity | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | regulation of ion transport | developmental process | positive regulation of anion transport | positive regulation of cell cycle process | cellular protein modification process | chronic inflammatory response to antigenic stimulus | positive regulation of prostaglandin secretion | regulation of monocyte chemotactic protein-1 production | regulation of chemokine production | positive regulation of interleukin-2 production | negative regulation of transcription by RNA polymerase II | carbohydrate derivative metabolic process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | heat generation | negative regulation of neural precursor cell proliferation | regulation of endothelial cell differentiation | regulation of fatty acid transport | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of granulocyte chemotaxis | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | regulation of defense response to virus by host | regulation of epithelial to mesenchymal transition | regulation of vascular endothelial growth factor production | positive regulation of interleukin-6 biosynthetic process | negative regulation of synaptic transmission | regulation of anion transport | positive regulation of nitric oxide biosynthetic process | positive regulation of JUN kinase activity | response to anesthetic | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | acute inflammatory response | regulation of interferon-gamma production | positive regulation of lipid transport | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of astrocyte differentiation | regulation of cell death | ectopic germ cell programmed cell death | positive regulation of cell motility | response to carbohydrate | response to steroid hormone | negative regulation of cell death | negative regulation of cell development | regulation of interleukin-6 production | neutrophil migration | regulation of branching morphogenesis of a nerve | regulation of inflammatory response | carbohydrate homeostasis | chemotaxis | divalent inorganic cation homeostasis | sexual reproduction | positive regulation of endocytosis | positive regulation of leukocyte cell-cell adhesion | positive regulation of angiogenesis | positive regulation of immature T cell proliferation in thymus | regulation of I-kappaB kinase/NF-kappaB signaling | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | response to other organism | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | regulation of p38MAPK cascade | positive regulation of fatty acid transport | positive regulation of gene expression | response to glucocorticoid | regulation of hormone biosynthetic process | glycosaminoglycan metabolic process | cellular response to lipopolysaccharide | macromolecule metabolic process | negative regulation of neurogenesis | positive regulation of interleukin-6 secretion | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | secretory vesicle | endomembrane system | vacuole | vesicle | lytic vacuole | extracellular region | membrane-bounded organelle | organelle | lysosome | extracellular space | intracellular vesicle | intracellular
