QuickView for IL-23A (gene)

Gene Symbol:

IL23A Homo sapiens

Full name:

interleukin 23 subunit alpha

Synonyms:

IL-23, IL-23A, IL23P19, P19, SGRF, interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, IL-23p19, JKA3 induced upon T-cell activation, interleukin 23 p19 subunit, interleukin 23, alpha subunit p19, interleukin-23 subunit p19, interleukin-six, G-CSF related factor

Genomic Location:

Chr 12: 55018930-55020461

Description:

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate ...

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This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  TGANTCA_AP1_C ,  STAT1_02 ,  RYTTCCTG_ETS2_B ,  TEL2_Q6 ,  YATTNATC_UNKNOWN ,  NFKAPPAB_01 ,  AP1_Q6 ,  STAT1_03 ,  AML1_01 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  CEBPDELTA_Q6 ,  CEBPB_01 ,  CAGGTA_AREB6_01 ,  CAGGTG_E12_Q6 ,  AP1FJ_Q2 ,  GGGCGGR_SP1_Q6 ,  E47_01 ,  AP1_Q4 ,  AML1_Q6 ,  ELK1_01 ,  CHOP_01 ,  RTTTNNNYTGGM_UNKNOWN ,  SMAD4_Q6 ,  AP1_Q2 ,  NFKB_Q6_01 ,  COREBINDINGFACTOR_Q6 ,  NFKB_Q6 ,  NFKB_C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-204

Cytogenetic Map:

12q13.3

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