QuickView for IL-27A (gene)

Gene Symbol:

IL27 Homo sapiens

Full name:

interleukin 27

Synonyms:

IL-27, IL-27A, IL27A, IL27p28, IL30, p28, interleukin-27 subunit alpha, IL-27 p28 subunit, IL-27 subunit alpha, IL-27-A, IL27-A, interleukin-30

Genomic Location:

Chr 16: 28418184-28425656

Description:

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T c...

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The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  TGANTCA_AP1_C ,  PR_01 ,  CEBP_Q2_01 ,  NFKAPPAB_01 ,  IRF1_Q6 ,  NFKAPPAB65_01 ,  AR_02 ,  CAGGTA_AREB6_01 ,  RREB1_01 ,  AREB6_01 ,  CEBPB_02 ,  HLF_01 ,  IRF7_01 ,  T3R_Q6 ,  CREL_01 ,  ICSBP_Q6 ,  NFKB_Q6_01 ,  ISRE_01 ,  PAX2_02 ,  NFKB_C ,  STTTCRNTTT_IRF_Q6 ,  IRF2_01

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Cytogenetic Map:

16p12.1-p11.2

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