QuickView for IL-28A (gene)

Gene Symbol:

IFNL2 Homo sapiens

Full name:

interferon lambda 2

Synonyms:

IL-28A, IL28A, interferon lambda-2, IFN-lambda-2, cytokine Zcyto20, interleukin 28A (interferon, lambda 2), interleukin-28A

Genomic Location:

Chr 19: 44450997-44452572

Description:

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral in...

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This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).

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Orthologs:

Mus musculus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  IRF1_Q6 ,  IRF_Q6 ,  ICSBP_Q6 ,  NFKB_Q6_01 ,  CAGCTG_AP4_Q5 ,  ISRE_01 ,  IRF2_01

Cytogenetic Map:

19q13.2

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