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QuickView for IL1A (gene)


Gene Symbol:
IL1A Homo sapiens Homo sapiens
Full name:
interleukin 1 alpha
Synonyms:
IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin-1 alpha, IL-1 alpha, hematopoietin-1, preinterleukin 1 alpha, pro-interleukin-1-alpha
Genomic Location:
Chr 2: 113247963-113259442
Description:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q14.1


Transcripts Names
NM_000575
Protein Names
P01583
Q7RU02
Q53QF9



GO Molecular Function

cation binding | signaling receptor binding | molecular function regulator | ion binding | copper ion binding | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity | transition metal ion binding | metal ion binding

GO Biological Process

regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | developmental process involved in reproduction | regulation of localization | regulation of programmed cell death | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | response to metal ion | cell differentiation | defense response | regulation of organelle organization | positive regulation of cellular component movement | positive regulation of protein secretion | positive regulation of cellular biosynthetic process | cellular process | regulation of cytokine biosynthetic process | regulation of cell motility | extrinsic apoptotic signaling pathway | tissue remodeling | negative regulation of signaling | regulation of mitotic nuclear division | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | response to inorganic substance | negative regulation of apoptotic signaling pathway | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of neutrophil migration | regulation of cellular extravasation | regulation of cell division | regulation of peptide secretion | regulation of vasculature development | response to stimulus | positive regulation of immune system process | positive regulation of protein metabolic process | response to stress | regulation of cell proliferation | multicellular organismal homeostasis | programmed cell death | positive regulation of cytokine biosynthetic process | reproduction | positive regulation of vascular endothelial growth factor production | positive regulation of cytokine secretion | response to temperature stimulus | regulation of protein transport | positive regulation of RNA biosynthetic process | regulation of peptide transport | molecular function regulator | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | apoptotic process | regulation of interleukin-2 biosynthetic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | positive regulation of neutrophil extravasation | inflammatory response to wounding | connective tissue replacement involved in inflammatory response wound healing | wound healing | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | positive regulation of secretion | cellular response to stress | regulation of neutrophil extravasation | cellular response to heat | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of interleukin-2 biosynthetic process | interleukin-1-mediated signaling pathway | cytokine-mediated signaling pathway | regulation of cellular component movement | regulation of transcription by RNA polymerase II | acute-phase response | negative regulation of extrinsic apoptotic signaling pathway | positive regulation of cell migration | cellular response to cytokine stimulus | cell proliferation | positive regulation of monocyte chemotactic protein-1 production | positive regulation of chemokine production | regulation of apoptotic signaling pathway | programmed cell death involved in cell development | regulation of leukocyte migration | positive regulation of cellular extravasation | cell communication | regulation of cellular metabolic process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | inflammatory response | regulation of protein metabolic process | homeostatic process | positive regulation of establishment of protein localization | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | apoptotic signaling pathway | fever generation | regulation of mitotic cell cycle | wound healing involved in inflammatory response | regulation of cytokine secretion | regulation of signaling receptor activity | receptor regulator activity | regulation of establishment of protein localization | response to organic substance | response to wounding | anatomical structure development | cell surface receptor signaling pathway | regulation of neutrophil migration | regulation of RNA biosynthetic process | negative regulation of programmed cell death | regulation of secretion | receptor ligand activity | positive regulation of interleukin-6 production | immune response | cytokine activity | response to copper ion | cell death | regulation of protein secretion | positive regulation of leukocyte migration | response to heat | positive regulation of cytokine production | temperature homeostasis | positive regulation of protein transport | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cell development | extrinsic apoptotic signaling pathway in absence of ligand | regulation of cytokine production | regulation of developmental process | developmental process | cellular response to interleukin-1 | positive regulation of cell cycle process | regulation of monocyte chemotactic protein-1 production | regulation of chemokine production | positive regulation of interleukin-2 production | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | heat generation | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | regulation of vascular endothelial growth factor production | positive regulation of metabolic process | acute inflammatory response | immune system process | cellular response to organic substance | regulation of protein localization | regulation of cell death | ectopic germ cell programmed cell death | positive regulation of cell motility | negative regulation of cell death | regulation of interleukin-6 production | positive regulation of angiogenesis | regulation of cellular component organization | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | positive regulation of gene expression | multicellular organismal process

GO Cellular Component

cell | cytoplasm | extracellular region | extracellular space | cytosol | intracellular