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QuickView for IL2RA (gene)


Gene Symbol:
IL2RA Homo sapiens Homo sapiens
Full name:
interleukin 2 receptor subunit alpha
Synonyms:
CD25, IDDM10, IL2R, IMD41, TCGFR, p55, interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2R subunit alpha, TAC antigen, interleukin 2 receptor, alpha
Genomic Location:
Chr 10: 6093512-6144278
Description:
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 10
10p15.1


Transcripts Names
NM_000417
NM_001308243
NM_001308242
Protein Names
Q5W005
P01589
Q5W007



GO Molecular Function

cytokine binding | guanyl-nucleotide exchange factor activity | GTPase binding | transmembrane signaling receptor activity | enzyme binding | interleukin-2 binding | Ras GTPase binding | growth factor binding | molecular function regulator | signaling receptor activity | cytokine receptor activity | protein binding | interleukin-2 receptor activity | Ras guanyl-nucleotide exchange factor activity | small GTPase binding | drug binding

GO Biological Process

leukocyte homeostasis | negative regulation of leukocyte activation | Notch signaling pathway | interleukin-2-mediated signaling pathway | negative regulation of immune system process | guanyl-nucleotide exchange factor activity | response to cytokine | intracellular signal transduction | cellular response to interleukin-2 | regulation of immune system process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | positive regulation of lymphocyte activation | regulation of T cell differentiation | defense response | positive regulation of cell adhesion | positive regulation of T cell differentiation | cellular process | negative regulation of inflammatory response | regulation of defense response to virus | negative regulation of T cell proliferation | regulation of cell differentiation | regulation of immune response | regulation of cellular process | positive regulation of activated T cell proliferation | negative regulation of mononuclear cell proliferation | MAPK cascade | response to stimulus | regulation of regulatory T cell differentiation | positive regulation of immune system process | signal transduction by protein phosphorylation | negative regulation of cell adhesion | response to stress | negative regulation of lymphocyte activation | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of cell-cell adhesion | inflammatory response to antigenic stimulus | programmed cell death | positive regulation of cell activation | positive regulation of T cell activation | protein modification process | regulation of cell adhesion | macromolecule modification | molecular function regulator | regulation of lymphocyte differentiation | apoptotic process | positive regulation of mononuclear cell proliferation | negative regulation of defense response to virus | nitrogen compound metabolic process | positive regulation of lymphocyte differentiation | phosphorus metabolic process | response to interleukin-2 | regulation of T cell activation | regulation of activated T cell proliferation | regulation of lymphocyte activation | regulation of tolerance induction | regulation of T cell homeostatic proliferation | negative regulation of T cell activation | cytokine-mediated signaling pathway | positive regulation of cell differentiation | homeostasis of number of cells | T cell apoptotic process | cellular response to cytokine stimulus | cell proliferation | positive regulation of T cell proliferation | negative regulation of immune response | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cytokine receptor activity | negative regulation of cell-cell adhesion | cell communication | lymphocyte homeostasis | negative regulation of cell activation | inflammatory response | homeostatic process | positive regulation of cell proliferation | activation-induced cell death of T cells | interleukin-2 receptor activity | protein metabolic process | response to organic substance | regulation of hemopoiesis | cell surface receptor signaling pathway | metabolic process | negative regulation of leukocyte proliferation | positive regulation of leukocyte activation | regulation of T cell tolerance induction | Ras guanyl-nucleotide exchange factor activity | immune response | organic substance metabolic process | cell death | regulation of cell activation | T cell homeostasis | signaling | regulation of T cell proliferation | cellular protein metabolic process | regulation of developmental process | cellular protein modification process | negative regulation of cell proliferation | regulation of cell-cell adhesion | negative regulation of lymphocyte proliferation | immune system process | cellular metabolic process | cellular response to organic substance | regulation of inflammatory response | positive regulation of leukocyte cell-cell adhesion | signal transduction | macromolecule metabolic process

GO Cellular Component

integral component of membrane | cell | intrinsic component of membrane | external side of plasma membrane | plasma membrane | cell periphery | cell surface | intracellular | membrane