QuickView for ILF3;jsessionid=48F476EEDA5C0C6C45D14ECEB383885F (gene)

Gene Symbol:

ILF3 Homo sapiens

Full name:

interleukin enhancer binding factor 3

Synonyms:

CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, NF-AT-90, NF110, NF110b, NF90, NF90a, NF90b, NFAR, NFAR-1, NFAR2, TCP110, TCP80, interleukin enhancer-binding factor 3, M-phase phosphoprotein 4, double-stranded RNA-binding protein, 76 kD, dsRNA binding protein NFAR-2/MPP4, interleukin enhancer binding factor 3, 90kD, interleukin enhancer binding factor 3, 90kDa, nuclear factor associated with dsRNA, nuclear factor of activated T-cells 90 kDa, nuclear factor of activated T-cells, 90 kD, translational control protein 80

Genomic Location:

Chr 19: 10625988-10664095

Description:

This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has b...

View Full Description

This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SMTTTTGT_UNKNOWN ,  TCANNTGAY_SREBP1_01 ,  ARNT_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  SYATTGTG_UNKNOWN ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  E2F4DP1_01 ,  MAX_01 ,  GCCATNTTG_YY1_Q6 ,  MYCMAX_B ,  COMP1_01 ,  GGGAGGRR_MAZ_Q6 ,  TCTAGAG_MIR517 ,  RYTGCNWTGGNR_UNKNOWN ,  E2F_Q6 ,  TITF1_Q3 ,  E2F1_Q6_01 ,  E2F_Q4 ,  GTTTGTT_MIR495 ,  MYCMAX_01 ,  GCAAAAA_MIR129 ,  GGGCGGR_SP1_Q6 ,  E2F1DP2_01 ,  AAGGGAT_MIR188 ,  SPZ1_01 ,  USF_01 ,  CAGCAGG_MIR370 ,  KCCGNSWTTT_UNKNOWN ,  E2F1DP1_01 ,  USF_Q6_01 ,  TTGTTT_FOXO4_01 ,  E2F1DP1RB_01 ,  E2F_02 ,  E2F1_Q3 ,  ACAWNRNSRCGG_UNKNOWN ,  E2F4DP2_01 ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  USF_02 ,  RRCCGTTA_UNKNOWN ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

19p13.2

search → result