QuickView for IMPA1 (gene)

Gene Symbol:

IMPA1 Homo sapiens

Full name:

inositol monophosphatase 1

Synonyms:

IMP, IMPA, MRT59, inositol monophosphatase 1, D-galactose 1-phosphate phosphatase, IMP 1, IMPase 1, inositol(myo)-1(or 4)-monophosphatase 1, inositol-1(or 4)-monophosphatase 1, lithium-sensitive myo-inositol monophosphatase A1, myo-inositol monophosphatase 1, testicular tissue protein Li 94

Genomic Location:

Chr 8: 82732751-82761115

Description:

This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-ino...

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This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

8q21.13

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