QuickView for IMPDH2 (gene)

Gene Symbol:

IMPDH2 Homo sapiens

Full name:

inosine monophosphate dehydrogenase 2

Synonyms:

IMPD2, IMPDH-II, inosine-5'-monophosphate dehydrogenase 2, IMP (inosine 5'-monophosphate) dehydrogenase 2, IMP (inosine monophosphate) dehydrogenase 2, IMP oxireductase 2, IMPD 2, IMPDH 2, inosine 5' phosphate dehydrogenase 2, inosine monophosphate dehydrogenase type II

Genomic Location:

Chr 3: 49036762-49041879

Description:

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted...

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This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACWWCAANK_UNKNOWN ,  RTAAACA_FREAC2_01 ,  PAX4_04 ,  TGIF_01 ,  E2F1_Q4_01 ,  FOXO4_01 ,  HFH1_01 ,  SREBP1_Q6 ,  TATAAA_TATA_01 ,  TITF1_Q3 ,  FOXO3_01 ,  E2F1_Q3_01 ,  NKX25_02 ,  FOXO1_01 ,  GCCNNNWTAAR_UNKNOWN ,  HFH8_01 ,  E2F_Q4_01 ,  TTGTTT_FOXO4_01 ,  E2F1DP1RB_01 ,  RTTTNNNYTGGM_UNKNOWN ,  WWTAAGGC_UNKNOWN ,  WTTGKCTG_UNKNOWN ,  BRN2_01 ,  AACTTT_UNKNOWN ,  PAX4_03 ,  E2F_Q3 ,  GGGTGGRR_PAX4_03

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Cytogenetic Map:

3p21.31

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