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QuickView for IQGAP1 (gene)


Gene Symbol:
IQGAP1 Homo sapiens Homo sapiens
Full name:
IQ motif containing GTPase activating protein 1
Synonyms:
HUMORFA01, SAR1, p195, ras GTPase-activating-like protein IQGAP1, RasGAP-like with IQ motifs
Genomic Location:
Chr 15: 88732477-88846479
Description:
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregula...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 15
15q26.1


Transcripts Names
NM_003870
XR_001751409
Protein Names
A7MBM3
A0A024RC65
P46940



GO Molecular Function

protein kinase activator activity | protein serine/threonine kinase activator activity | kinase binding | enzyme activator activity | protein kinase regulator activity | GTPase binding | Rho GTPase binding | cadherin binding | cation binding | S100 protein binding | kinase regulator activity | GTPase activator activity | protein kinase binding | enzyme binding | mitogen-activated protein kinase binding | protein-containing complex binding | lipid binding | enzyme inhibitor activity | GTPase regulator activity | phospholipid binding | Ras GTPase binding | molecular function regulator | protein domain specific binding | anion binding | ion binding | phosphatidylinositol-3,4,5-trisphosphate binding | cell adhesion molecule binding | protein binding | protein phosphatase binding | kinase activator activity | Rac GTPase binding | phosphatidylinositol binding | small GTPase binding | calcium ion binding | enzyme regulator activity | calmodulin binding | phosphatase binding | metal ion binding | GTPase inhibitor activity | phosphatidylinositol phosphate binding

GO Biological Process

cell morphogenesis | protein kinase activator activity | positive regulation of locomotion | regulation of dephosphorylation | protein serine/threonine kinase activator activity | exocytosis | positive regulation of cellular component organization | regulation of neurogenesis | neuron projection morphogenesis | neutrophil activation | positive regulation of adherens junction organization | regulation of cellular localization | enzyme activator activity | cellular response to platelet-derived growth factor stimulus | regulation of cell development | regulation of localization | protein kinase regulator activity | positive regulation of peptidyl-tyrosine phosphorylation | establishment of localization | response to hormone | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | response to metal ion | cell differentiation | glomerulus development | nervous system development | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | generation of neurons | positive regulation of GTPase activity | neuron projection extension | cellular process | secretion | leukocyte degranulation | regulation of cell motility | localization | cell projection morphogenesis | developmental growth | neuron development | kinase regulator activity | GTPase activator activity | positive regulation of protein kinase activity | glomerular visceral epithelial cell development | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of cell differentiation | regulation of cellular process | leukocyte activation | regulation of metabolic process | epidermal growth factor receptor signaling pathway | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | cellular response to metal ion | urogenital system development | response to stimulus | enzyme inhibitor activity | regulation of cellular protein localization | neutrophil degranulation | cellular response to fibroblast growth factor stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | GTPase regulator activity | leukocyte activation involved in immune response | positive regulation of cellular protein localization | response to peptide | epithelial cell development | regulation of smooth muscle cell migration | cellular response to inorganic substance | secretion by cell | ERBB signaling pathway | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | regulation of cell adhesion | kidney development | activation of protein kinase activity | positive regulation of cell-matrix adhesion | molecular function regulator | positive regulation of vascular associated smooth muscle cell migration | response to nitrogen compound | positive regulation of cell junction assembly | system development | regulation of signal transduction | negative regulation of phosphate metabolic process | positive regulation of neuron projection development | regulation of adherens junction organization | multicellular organism development | negative regulation of catalytic activity | regulation of MAPK cascade | positive regulation of smooth muscle cell migration | leukocyte mediated immunity | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | fibroblast growth factor receptor signaling pathway | regulation of neuron differentiation | kidney epithelium development | platelet-derived growth factor receptor signaling pathway | regulation of protein autophosphorylation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of cellular component movement | positive regulation of hydrolase activity | positive regulation of cell differentiation | response to platelet-derived growth factor | positive regulation of cell migration | regulation of cellular protein metabolic process | cell differentiation involved in kidney development | regulated exocytosis | regulation of GTPase activity | positive regulation of peptidyl-tyrosine autophosphorylation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | regulation of protein phosphorylation | regulation of locomotion | renal system development | positive regulation of dendrite development | regulation of mitotic cell cycle | nephron development | glomerular visceral epithelial cell differentiation | positive regulation of molecular function | cellular response to epidermal growth factor stimulus | response to angiotensin | neuron differentiation | positive regulation of focal adhesion assembly | positive regulation of protein modification process | cellular response to calcium ion | response to organic substance | regulation of kinase activity | regulation of intracellular signal transduction | regulation of focal adhesion assembly | anatomical structure development | developmental growth involved in morphogenesis | kinase activator activity | cell surface receptor signaling pathway | positive regulation of neurogenesis | cell projection organization | positive regulation of cell development | immune response | neuron projection development | positive regulation of cellular component biogenesis | animal organ development | positive regulation of cell-substrate adhesion | positive regulation of kinase activity | regulation of phosphate metabolic process | cell activation | positive regulation of MAPK cascade | response to epidermal growth factor | regulation of dendrite development | regulation of cell communication | negative regulation of molecular function | signaling | cell development | positive regulation of phosphorylation | enzyme regulator activity | regulation of cytokine production | anatomical structure morphogenesis | positive regulation of MAP kinase activity | regulation of nervous system development | regulation of developmental process | developmental process | positive regulation of protein autophosphorylation | regulation of cell junction assembly | developmental cell growth | response to fibroblast growth factor | negative regulation of GTPase activity | neutrophil mediated immunity | response to organonitrogen compound | negative regulation of dephosphorylation | epithelial cell differentiation | negative regulation of hydrolase activity | response to calcium ion | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | positive regulation of neuron differentiation | regulation of cell projection organization | immune system process | cellular response to organic substance | regulation of protein localization | positive regulation of cell motility | GTPase inhibitor activity | glomerular epithelium development | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | regulation of cell-matrix adhesion | cellular response to growth factor stimulus | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | supramolecular fiber | cytoplasmic side of plasma membrane | intracellular membrane-bounded organelle | neuron projection | extrinsic component of membrane | ruffle | adherens junction | organelle membrane | focal adhesion | cytoplasmic vesicle | cell | cytoplasmic side of membrane | extrinsic component of plasma membrane | distal axon | ribonucleoprotein granule | microtubule | cytoplasm | cell-substrate junction | intracellular organelle | actin cytoskeleton | membrane microdomain | secretory granule membrane | cell-cell junction | protein-containing complex | cell projection | secretory vesicle | endomembrane system | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | midbody | cell leading edge | membrane raft | ribonucleoprotein complex | vesicle | extracellular exosome | microtubule cytoskeleton | site of polarized growth | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | vesicle membrane | extracellular space | cell periphery | axon | cell-substrate adherens junction | growth cone | cytosol | intracellular vesicle | actin filament | cytoskeleton | slit diaphragm | intracellular | cell junction | lateral plasma membrane | membrane | supramolecular complex | cytoplasmic vesicle membrane