QuickView for IRF1 (gene)

Gene Symbol:

IRF1 Homo sapiens

Full name:

interferon regulatory factor 1

Synonyms:

IRF-1, MAR, interferon regulatory factor 1, interferon regulatory factor 1 isoform +I9, interferon regulatory factor 1 isoform d78, interferon regulatory factor 1 isoform d9,10+, interferon regulatory factor 1 isoform delta4, interferon regulatory factor 1 isoform delta7

Genomic Location:

Chr 5: 131846679-131854326

Description:

The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune re...

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The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q6 ,  TCTGATC_MIR383 ,  NFKAPPAB_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  STAT1_03 ,  AP2ALPHA_01 ,  RGAANNTTC_HSF1_01 ,  STAT3_02 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  E47_02 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  E47_01 ,  STAT3_01 ,  STAT_01 ,  GTGCCTT_MIR506 ,  AATGTGA_MIR23A_MIR23B ,  GGCACTT_MIR519E ,  AP2_Q6 ,  STAT5A_01 ,  AACTTT_UNKNOWN ,  NFKB_C ,  GGGTGGRR_PAX4_03 ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-383 ,  Predicted Gene Targets for miR-124a

Cytogenetic Map:

5q31.1

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