QuickView for IRF3;jsessionid=D2B2803848631C6706696A45CB435EAD (gene)
- Gene Symbol:
- IRF3
Homo sapiens - Full name:
- interferon regulatory factor 3
- Synonyms:
- IIAE7, interferon regulatory factor 3
- Genomic Location:
- Chr 19: 54854641-54860936
- Description:
-
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other inter...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Bos taurus , Danio rerio , Pan troglodytes
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
19q13.33
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | protein domain specific binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | identical protein binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transcription coregulator activity | heterocyclic compound binding
GO Biological Process
positive regulation of immune response | RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | response to virus | negative regulation of immune system process | response to cytokine | immune response-regulating signaling pathway | response to lipopolysaccharide | negative regulation of type I interferon production | intracellular signal transduction | regulation of localization | cellular response to type I interferon | defense response to other organism | regulation of immune system process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | regulation of interferon-beta biosynthetic process | defense response | macrophage apoptotic process | positive regulation of protein secretion | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | toll-like receptor signaling pathway | response to exogenous dsRNA | response to type I interferon | regulation of cytokine biosynthetic process | cytoplasmic pattern recognition receptor signaling pathway in response to virus | programmed necrotic cell death | negative regulation of nucleic acid-templated transcription | regulation of response to cytokine stimulus | regulation of defense response to virus | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | interspecies interaction between organisms | regulation of interferon-beta production | regulation of immune response | regulation of cellular process | cellular response to lipid | regulation of metabolic process | interferon-gamma-mediated signaling pathway | cellular response to molecule of bacterial origin | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular response to interferon-gamma | inflammatory cell apoptotic process | positive regulation of type I interferon-mediated signaling pathway | regulation of peptide secretion | regulation of type I interferon production | response to stimulus | positive regulation of innate immune response | positive regulation of immune system process | response to stress | cellular nitrogen compound biosynthetic process | programmed cell death | activation of innate immune response | positive regulation of cytokine secretion | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | immune response-activating signal transduction | cellular response to organic cyclic compound | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of peptide transport | cellular biosynthetic process | negative regulation of interferon-beta biosynthetic process | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | positive regulation of response to cytokine stimulus | response to nitrogen compound | apoptotic process | negative regulation of defense response to virus | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | pattern recognition receptor signaling pathway | response to dsRNA | type I interferon production | cellular response to DNA damage stimulus | negative regulation of defense response to virus by host | regulation of gene expression | positive regulation of secretion | cellular response to stress | response to lipid | negative regulation of cytokine production | positive regulation of cellular metabolic process | defense response to virus | regulation of nitrogen compound metabolic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | MDA-5 signaling pathway | cellular response to cytokine stimulus | biosynthetic process | TRIF-dependent toll-like receptor signaling pathway | aromatic compound biosynthetic process | negative regulation of cytokine biosynthetic process | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | cellular response to dsRNA | positive regulation of establishment of protein localization | regulation of cytokine-mediated signaling pathway | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | positive regulation of transport | viral process | cellular response to virus | positive regulation of interferon-alpha production | negative regulation of interferon-beta production | regulation of cytokine secretion | cytokine production | activation of immune response | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | regulation of establishment of protein localization | response to organic substance | regulation of innate immune response | MyD88-independent toll-like receptor signaling pathway | regulation of intracellular signal transduction | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | type I interferon biosynthetic process | regulation of secretion | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of biosynthetic process | regulation of type I interferon-mediated signaling pathway | negative regulation of gene expression | gene expression | regulation of protein secretion | transcription, DNA-templated | response to interferon-gamma | positive regulation of cytokine production | intracellular receptor signaling pathway | positive regulation of protein transport | negative regulation of protein metabolic process | positive regulation of cytokine-mediated signaling pathway | type I interferon signaling pathway | regulation of cell communication | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | regulation of cytokine production | cellular macromolecule biosynthetic process | response to biotic stimulus | cytokine biosynthetic process | myeloid cell apoptotic process | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | necrotic cell death | innate immune response | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | regulation of defense response to virus by host | cytokine metabolic process | heterocycle metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | positive regulation of type I interferon production | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to lipopolysaccharide | macromolecule metabolic process | positive regulation of interferon-beta production | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
