QuickView for IRF4 (gene)
- Gene Symbol:
- IRF4
Homo sapiens - Full name:
- interferon regulatory factor 4
- Synonyms:
- LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4, lymphocyte-specific interferon regulatory factor, multiple myeloma oncogene 1
- Genomic Location:
- Chr 6: 336760-356193
- Description:
-
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
6p25.3
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | lysine N-methyltransferase activity | protein methyltransferase activity | proximal promoter sequence-specific DNA binding | nucleic acid binding | S-adenosylmethionine-dependent methyltransferase activity | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | catalytic activity | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | N-methyltransferase activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transferase activity | protein-lysine N-methyltransferase activity | methyltransferase activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | adaptive immune response | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | CD4-positive, alpha-beta T cell differentiation | response to cytokine | CD4-positive, alpha-beta T cell activation | T cell lineage commitment | peptidyl-amino acid modification | cellular response to type I interferon | defense response to other organism | regulation of immune system process | myeloid cell differentiation | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | histone modification | T-helper cell lineage commitment | cell differentiation | regulation of T cell differentiation | defense response | lysine N-methyltransferase activity | histone H3 acetylation | protein methyltransferase activity | positive regulation of cellular biosynthetic process | cellular process | lymphocyte differentiation | T-helper 17 cell differentiation | response to type I interferon | regulation of cytokine biosynthetic process | chromatin organization | negative regulation of signaling | immune system development | positive regulation of interleukin-10 biosynthetic process | myeloid dendritic cell differentiation | positive regulation of nitrogen compound metabolic process | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | regulation of binding | regulation of cell differentiation | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | interferon-gamma-mediated signaling pathway | T cell differentiation involved in immune response | S-adenosylmethionine-dependent methyltransferase activity | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | positive regulation of interleukin-4 production | cellular component organization | negative regulation of toll-like receptor signaling pathway | T cell activation | cellular response to interferon-gamma | histone H4 acetylation | response to stimulus | positive regulation of cold-induced thermogenesis | alpha-beta T cell activation involved in immune response | positive regulation of protein metabolic process | regulation of CD4-positive, alpha-beta T cell activation | response to stress | leukocyte activation involved in immune response | cellular nitrogen compound biosynthetic process | T-helper 17 cell lineage commitment | positive regulation of cytokine biosynthetic process | peptidyl-lysine acetylation | cellular nitrogen compound metabolic process | regulation of DNA binding | myeloid dendritic cell activation | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | cellular biosynthetic process | macromolecule modification | positive regulation of interleukin-13 biosynthetic process | regulation of lymphocyte differentiation | regulation of nucleic acid-templated transcription | T-helper cell differentiation | leukocyte differentiation | regulation of interleukin-2 biosynthetic process | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | regulation of interleukin-4 production | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | protein acetylation | regulation of toll-like receptor signaling pathway | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell activation | regulation of gene expression | methylation | alpha-beta T cell lineage commitment | myeloid leukocyte differentiation | positive regulation of cellular metabolic process | regulation of lymphocyte activation | positive regulation of interleukin-4 biosynthetic process | regulation of nitrogen compound metabolic process | positive regulation of interleukin-2 biosynthetic process | cytokine-mediated signaling pathway | regulation of transcription by RNA polymerase II | alpha-beta T cell differentiation | positive regulation of interleukin-13 production | cellular response to cytokine stimulus | histone acetylation | internal peptidyl-lysine acetylation | biosynthetic process | aromatic compound biosynthetic process | T cell activation involved in immune response | defense response to protozoan | cell communication | regulation of cellular metabolic process | regulation of alpha-beta T cell differentiation | cell activation involved in immune response | regulation of protein metabolic process | regulation of RNA metabolic process | lymphocyte activation | positive regulation of molecular function | T cell differentiation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | T cell selection | response to organic substance | regulation of innate immune response | peptidyl-lysine methylation | regulation of hemopoiesis | N-methyltransferase activity | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cell fate commitment | dendritic cell differentiation | regulation of RNA biosynthetic process | positive T cell selection | peptidyl-lysine modification | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | animal organ development | gene expression | regulation of cell activation | response to protozoan | alpha-beta T cell activation | positive regulation of binding | transcription, DNA-templated | response to interferon-gamma | positive regulation of cytokine production | cell activation | regulation of T-helper cell differentiation | type I interferon signaling pathway | regulation of cell communication | positive regulation of interleukin-10 production | negative regulation of signal transduction | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | protein-lysine N-methyltransferase activity | positive regulation of DNA binding | internal protein amino acid acetylation | cellular protein metabolic process | regulation of cytokine production | cellular macromolecule biosynthetic process | protein methylation | response to biotic stimulus | regulation of developmental process | methyltransferase activity | developmental process | organelle organization | cellular protein modification process | positive regulation of interleukin-2 production | positive regulation of transcription, DNA-templated | innate immune response | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | response to other organism | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | nuclear nucleosome | cytoplasm | nucleosome | intracellular organelle | protein-containing complex | protein-DNA complex | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular | membrane
