QuickView for IRS1 (gene)

Gene Symbol:

IRS1 Homo sapiens

Full name:

insulin receptor substrate 1

Synonyms:

HIRS-1, insulin receptor substrate 1, IRS-1

Genomic Location:

Chr 2: 227308182-227372719

Description:

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  CACTGTG_MIR128A_MIR128B ,  GTGCCAT_MIR183 ,  TGIF_01 ,  RSRFC4_01 ,  AAAYWAACM_HFH4_01 ,  RSRFC4_Q2 ,  AACTGGA_MIR145 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  MEIS1BHOXA9_01 ,  GATAAGR_GATA_C ,  CTAWWWATA_RSRFC4_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  GGGAGGRR_MAZ_Q6 ,  MEF2_02 ,  TATAAA_TATA_01 ,  TFIII_Q6 ,  CAGGTA_AREB6_01 ,  ALPHACP1_01 ,  NKX62_Q2 ,  SP3_Q3 ,  TGCTGAY_UNKNOWN ,  GTGCCAA_MIR96 ,  YKACATTT_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  AP2_Q3 ,  TGTTTGY_HNF3_Q6 ,  TTGTTT_FOXO4_01 ,  MEF2_03 ,  SMAD4_Q6 ,  CTGCAGY_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  GCTNWTTGK_UNKNOWN ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-126 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-487b ,  Predicted Gene Targets for miR-96

miRNA binding sites
(Source: miRecords):

hsa-miR-145 Targeted Genes ,  hsa-miR-7 Targeted Genes

Cytogenetic Map:

2q36.3

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