QuickView for IRS2;jsessionid=35AAE21D68A6D86C30868AEC78D23342 (gene)

Gene Symbol:

IRS2 Homo sapiens

Full name:

insulin receptor substrate 2

Synonyms:

IRS-2, insulin receptor substrate 2

Genomic Location:

Chr 13: 109204185-109236915

Description:

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kina...

View Full Description

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  EFC_Q6 ,  CAGTGTT_MIR141_MIR200A ,  IRF1_Q6 ,  CTTTGTA_MIR524 ,  CATTTCA_MIR203 ,  RFX1_02 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  GTCTTCC_MIR7 ,  GGGCGGR_SP1_Q6 ,  ATGTTAA_MIR302C ,  TGCCAAR_NF1_Q6 ,  ATATGCA_MIR448 ,  CAATGCA_MIR33

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-499

View More

View Less

miRNA binding sites
(Source: miRecords):

hsa-miR-7 Targeted Genes

Cytogenetic Map:

13q34

search → result