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QuickView for ISL1;jsessionid=5DEFB28AA6506D852E208E7810A68700 (gene)


Gene Symbol:
ISL1 Homo sapiens Homo sapiens
Full name:
ISL LIM homeobox 1
Synonyms:
ISLET1, Isl-1, insulin gene enhancer protein ISL-1, ISL1 transcription factor, LIM/homeodomain, islet-1
Genomic Location:
Chr 5: 50714715-50726321
Description:
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor ...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
CACTGTG_MIR128A_MIR128B OCT1_07 RTAAACA_FREAC2_01 OCT1_05 SMTTTTGT_UNKNOWN HNF1_01 TTANTCA_UNKNOWN OCT1_04 GATA3_01 FOXO4_01
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5q11.1


Transcripts Names
NM_002202
XM_011543380
Protein Names
P61371
P47894
P20663



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | cation binding | hormone receptor binding | proximal promoter sequence-specific DNA binding | RNA polymerase II activating transcription factor binding | nucleic acid binding | estrogen receptor binding | signaling receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | bHLH transcription factor binding | DNA binding | sequence-specific double-stranded DNA binding | promoter-specific chromatin binding | nuclear hormone receptor binding | ion binding | organic cyclic compound binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nuclear receptor binding | steroid hormone receptor binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | brain development | regulation of interleukin-1 beta production | cell morphogenesis | ventricular cardiac muscle tissue morphogenesis | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | cell motility | pharyngeal system development | regulation of neurogenesis | neuron projection morphogenesis | muscle tissue development | regulation of cell development | regulation of localization | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | spinal cord motor neuron differentiation | response to hormone | negative regulation of neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | nervous system development | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | regulation of peptide hormone secretion | generation of neurons | positive regulation of protein secretion | mesenchyme development | cardiac atrium morphogenesis | pattern specification process | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | peripheral nervous system development | negative regulation of inflammatory response | localization | cell projection morphogenesis | negative regulation of protein homodimerization activity | heart morphogenesis | negative regulation of signaling | neuron development | central nervous system neuron differentiation | positive regulation of epithelial to mesenchymal transition | negative regulation of nucleic acid-templated transcription | positive regulation of macrophage colony-stimulating factor production | regulation of histone modification | negative regulation of apoptotic process | axon guidance | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | diencephalon development | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | muscle structure development | regeneration | regulation of angiogenesis | positive regulation of granulocyte macrophage colony-stimulating factor production | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | pituitary gland development | cardiac cell fate determination | positive regulation of interferon-gamma production | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | positive regulation of tumor necrosis factor production | head development | cranial nerve development | sensory system development | regulation of peptide secretion | muscle organ morphogenesis | spinal cord motor neuron cell fate specification | regulation of vasculature development | response to stimulus | positive regulation of interleukin-1 beta production | cardiac right ventricle morphogenesis | cell morphogenesis involved in neuron differentiation | mesenchymal cell development | regulation of peptidyl-tyrosine phosphorylation | regulation of insulin secretion | positive regulation of protein metabolic process | regulation of cardioblast proliferation | response to stress | neuron projection guidance | regulation of intracellular steroid hormone receptor signaling pathway | positive regulation of JAK-STAT cascade | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | cardiac muscle tissue development | muscle tissue morphogenesis | regulation of protein homodimerization activity | positive regulation of vascular endothelial growth factor production | cardiac ventricle morphogenesis | heart formation | cellular nitrogen compound metabolic process | retinal ganglion cell axon guidance | positive regulation of hormone secretion | regulation of DNA binding | cellular response to organic cyclic compound | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of peptide transport | cellular biosynthetic process | embryo development | neuron fate commitment | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | locomotion | negative regulation of neuron apoptotic process | cellular response to hormone stimulus | endocardial cushion development | system development | ventral spinal cord development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | peripheral nervous system neuron axonogenesis | multicellular organism development | positive regulation of granulocyte colony-stimulating factor production | cell migration | regulation of intracellular estrogen receptor signaling pathway | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | positive regulation of chromosome organization | positive regulation of interleukin-1 alpha production | regulation of neuron differentiation | regulation of gene expression | pancreas development | axon development | positive regulation of secretion | outflow tract morphogenesis | cellular response to stress | response to lipid | endocardial cushion morphogenesis | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | response to axon injury | animal organ morphogenesis | specification of animal organ identity | regulation of nitrogen compound metabolic process | cardiac atrium development | positive regulation of STAT cascade | positive regulation of interleukin-12 production | positive regulation of intracellular signal transduction | cardiocyte differentiation | response to corticosteroid | regulation of transcription by RNA polymerase II | axonogenesis | negative regulation of binding | positive regulation of cell differentiation | stem cell differentiation | negative regulation of intracellular steroid hormone receptor signaling pathway | regulation of cell proliferation involved in heart morphogenesis | biosynthetic process | innervation | neuron projection regeneration | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | cellular response to glucocorticoid stimulus | mesenchyme morphogenesis | cardiac septum morphogenesis | endocrine system development | regulation of tumor necrosis factor production | cell morphogenesis involved in differentiation | cellular response to corticosteroid stimulus | neural crest cell migration | regulation of interleukin-1 production | chordate embryonic development | animal organ formation | striated muscle tissue development | cardiac muscle tissue morphogenesis | negative regulation of protein binding | regulation of cellular metabolic process | regulation of neuron apoptotic process | positive regulation of interleukin-1 production | regulation of macrophage colony-stimulating factor production | positive regulation of tyrosine phosphorylation of STAT protein | visceral motor neuron differentiation | regulation of protein metabolic process | positive regulation of signal transduction | heart development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | transcription coactivator activity | regulation of RNA metabolic process | positive regulation of protein acetylation | positive regulation of transport | positive regulation of peptide hormone secretion | negative regulation of intracellular estrogen receptor signaling pathway | positive regulation of molecular function | neuron differentiation | negative regulation of epithelial cell proliferation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regulation of establishment of protein localization | regionalization | cardiac ventricle development | positive regulation of protein modification process | response to organic substance | gland development | positive regulation of insulin secretion | tissue morphogenesis | regulation of JAK-STAT cascade | response to wounding | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | positive regulation of peptidyl-lysine acetylation | ventricular cardiac muscle tissue development | anatomical structure development | cell projection organization | metabolic process | cell fate commitment | mesenchymal cell differentiation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | peripheral nervous system neuron development | regulation of secretion | heart field specification | positive regulation of interleukin-6 production | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | neuron projection development | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | forebrain development | negative regulation of neuron differentiation | nerve development | gene expression | regulation of protein secretion | regulation of heart morphogenesis | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | regulation of chromosome organization | cellular response to steroid hormone stimulus | positive regulation of binding | transcription, DNA-templated | positive regulation of cytokine production | atrial septum development | stem cell development | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | cell differentiation in spinal cord | regulation of animal organ formation | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | regulation of secondary heart field cardioblast proliferation | myoblast differentiation | cell development | positive regulation of DNA binding | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cardioblast differentiation | regulation of cytokine production | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | trigeminal nerve development | axon regeneration | regulation of nervous system development | regulation of developmental process | developmental process | negative regulation of canonical Wnt signaling pathway | cardiac septum development | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | positive regulation of histone acetylation | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | cardiac muscle cell myoblast differentiation | atrial septum morphogenesis | positive regulation of nucleic acid-templated transcription | cell fate determination | neural crest cell differentiation | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | secondary heart field specification | cardiac chamber development | heterocycle metabolic process | regulation of vascular endothelial growth factor production | central nervous system development | spinal cord development | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | regulation of interferon-gamma production | cellular metabolic process | ameboidal-type cell migration | cellular response to organic substance | regulation of protein localization | regulation of cell death | response to steroid hormone | peripheral nervous system neuron differentiation | negative regulation of cell death | negative regulation of cell development | regulation of interleukin-6 production | neuron fate specification | circulatory system development | regulation of inflammatory response | chemotaxis | neural crest cell development | positive regulation of angiogenesis | negative regulation of cell differentiation | regulation of cellular component organization | muscle organ development | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | response to glucocorticoid | outflow tract septum morphogenesis | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of chromatin organization | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular