QuickView for ITGA2;jsessionid=B16F658CFDAE1C4995B76DC0482D3A6F (gene)

Gene Symbol:

ITGA2 Homo sapiens

Full name:

integrin subunit alpha 2

Synonyms:

BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin alpha-2, CD49 antigen-like family member B, alpha 2 subunit of VLA-2 receptor, collagen receptor, human platelet alloantigen system 5, integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), platelet antigen Br, platelet glycoprotein GPIa, platelet membrane glycoprotein Ia, very late activation protein 2 receptor, alpha-2 subunit

Genomic Location:

Chr 5: 52320913-52426366

Description:

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against ...

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This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  E12_Q6 ,  TGANTCA_AP1_C ,  GCANCTGNY_MYOD_Q6 ,  LYF1_01 ,  STAT6_01 ,  CAGGTG_E12_Q6 ,  ATGCTGC_MIR103_MIR107 ,  STAT5A_03 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  GTGGGTGK_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-15

Cytogenetic Map:

5q11.2

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