QuickView for ITGA5 (gene)

Gene Symbol:

ITGA5 Homo sapiens

Full name:

integrin subunit alpha 5

Synonyms:

CD49e, FNRA, VLA-5, VLA5A, integrin alpha-5, CD49 antigen-like family member E, fibronectin receptor subunit alpha, fibronectin receptor, alpha polypeptide, fibronectin receptor, alpha subunit, integrin alpha-F, integrin, alpha 5 (fibronectin receptor, alpha polypeptide), very late activation protein 5, alpha subunit

Genomic Location:

Chr 12: 53075312-53099317

Description:

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit....

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The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  CMYB_01 ,  MZF1_01 ,  GATA_C ,  TACTTGA_MIR26A_MIR26B ,  ACTGTGA_MIR27A_MIR27B ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  GGGAGGRR_MAZ_Q6 ,  CEBPDELTA_Q6 ,  CEBPB_01 ,  CACCCBINDINGFACTOR_Q6 ,  RREB1_01 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  HNF4_Q6 ,  AGGGCCA_MIR328 ,  CCCNNNNNNAAGWT_UNKNOWN ,  PAX4_03 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-31

Cytogenetic Map:

12q13.13

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