QuickView for ITGA6 (gene)

Gene Symbol:

ITGA6 Homo sapiens

Full name:

integrin subunit alpha 6

Synonyms:

CD49f, ITGA6B, VLA-6, integrin alpha-6, CD49 antigen-like family member F, integrin alpha6B, integrin, alpha 6

Genomic Location:

Chr 2: 173000560-173079427

Description:

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit...

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The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  MYOD_Q6_01 ,  TTTGCAC_MIR19A_MIR19B ,  PR_02 ,  MAZR_01 ,  MYOD_01 ,  GCATTTG_MIR105 ,  PR_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  E2A_Q2 ,  CAGGTG_E12_Q6 ,  AR_03 ,  MYOD_Q6 ,  ATTCTTT_MIR186 ,  GCAAAAA_MIR129 ,  GGGCGGR_SP1_Q6 ,  E47_01 ,  AR_Q2 ,  AREB6_03 ,  GR_01 ,  MYOGENIN_Q6 ,  CAGCTG_AP4_Q5 ,  CACBINDINGPROTEIN_Q6 ,  TCATCTC_MIR143 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-126 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-487b ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-542-5p

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Cytogenetic Map:

2q31.1

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