QuickView for ITGAV;jsessionid=1C29E3B8784D6D316B78B7A7FABD91E0 (gene)

Gene Symbol:

ITGAV Homo sapiens

Full name:

integrin subunit alpha V

Synonyms:

CD51, MSK8, VNRA, VTNR, integrin alpha-V, antigen identified by monoclonal antibody L230, integrin alphaVbeta3, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), vitronectin receptor subunit alpha

Genomic Location:

Chr 2: 187163045-187253873

Description:

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit....

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The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CCCACAT_MIR2993P ,  ATTACAT_MIR3803P ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  ACACTAC_MIR1423P

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-299-3p

Cytogenetic Map:

2q32.1

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