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QuickView for ITGB2 (gene)


Gene Symbol:
ITGB2 Homo sapiens Homo sapiens
Full name:
integrin subunit beta 2
Synonyms:
CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin beta-2, cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor), complement component 3 receptor 3 and 4 subunit, complement receptor C3 beta-subunit, integrin beta chain, beta 2, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), leukocyte cell adhesion molecule CD18, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
Genomic Location:
Chr 21: 45130296-45165303
Description:
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cau...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 21
21q22.3





GO Molecular Function

kinase binding | peptide binding | opsonin binding | amyloid-beta binding | cation binding | protein kinase binding | transmembrane signaling receptor activity | enzyme binding | protein-containing complex binding | complement binding | signaling receptor binding | complement component C3b binding | amide binding | signaling receptor activity | ICAM-3 receptor activity | protein heterodimerization activity | ion binding | integrin binding | cell adhesion molecule binding | protein binding | protein dimerization activity | heat shock protein binding | metal ion binding

GO Biological Process

positive regulation of immune response | regulation of intracellular protein transport | exocytosis | extracellular structure organization | response to cytokine | cell motility | regulation of cell morphogenesis | immune response-regulating signaling pathway | neutrophil activation | regulation of cellular localization | phagocytosis, engulfment | regulation of localization | cell-substrate adhesion | positive regulation of DNA-binding transcription factor activity | heterotypic cell-cell adhesion | establishment of localization | regulation of immune system process | regulation of nitric oxide biosynthetic process | regulation of cell shape | negative regulation of cellular process | integrin-mediated signaling pathway | positive regulation of developmental process | regulation of protein localization to membrane | cell differentiation | positive regulation of prostaglandin-E synthase activity | defense response | epithelial cell migration | membrane organization | regulation of neutrophil degranulation | regulation of neuron death | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | secretion | toll-like receptor signaling pathway | leukocyte degranulation | localization | positive regulation of immune effector process | positive regulation of reactive oxygen species metabolic process | epithelium migration | positive regulation of macrophage activation | macromolecule localization | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | granulocyte chemotaxis | negative regulation of cellular metabolic process | tissue development | cellular response to low-density lipoprotein particle stimulus | regulation of angiogenesis | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | cellular component organization | regulation of vasculature development | response to stimulus | regulation of cellular protein localization | neutrophil degranulation | positive regulation of innate immune response | neutrophil chemotaxis | regulation of peptidyl-tyrosine phosphorylation | positive regulation of nitric oxide metabolic process | positive regulation of immune system process | cell adhesion mediated by integrin | response to stress | endothelial cell migration | leukocyte activation involved in immune response | positive regulation of cellular protein localization | receptor clustering | programmed cell death | positive regulation of cell activation | activation of innate immune response | cellular localization | secretion by cell | positive regulation of superoxide anion generation | regulation of dopamine metabolic process | immune response-activating signal transduction | extracellular matrix organization | regulation of protein transport | negative regulation of metabolic process | regulation of peptide transport | embryo development | cell-cell signaling | cell chemotaxis | regulation of intracellular transport | leukocyte migration | regulation of catecholamine metabolic process | regulation of nucleic acid-templated transcription | positive regulation of exocytosis | regulation of neurotransmitter levels | locomotion | response to nitrogen compound | apoptotic process | positive regulation of reactive oxygen species biosynthetic process | regulation of superoxide metabolic process | pattern recognition receptor signaling pathway | multicellular organism development | cell migration | leukocyte mediated immunity | regulation of catalytic activity | regulation of phosphorylation | localization within membrane | positive regulation of neutrophil degranulation | regulation of gene expression | protein localization to membrane | positive regulation of secretion | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | amyloid-beta clearance | cytokine-mediated signaling pathway | vesicle-mediated transport | endoderm formation | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | regulated exocytosis | positive regulation of neuron death | microglial cell activation | positive regulation of regulated secretory pathway | regulation of macrophage activation | cell communication | regulation of cellular metabolic process | positive regulation of protein localization to membrane | receptor internalization | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | neutrophil activation involved in immune response | leukocyte chemotaxis | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of transport | cellular response to lipoprotein particle stimulus | embryonic morphogenesis | lymphocyte activation | positive regulation of molecular function | activation of immune response | regulation of establishment of protein localization | response to organic substance | regulation of innate immune response | negative regulation of dopamine metabolic process | import into cell | regulation of DNA-binding transcription factor activity | regulation of exocytosis | anatomical structure development | cell surface receptor signaling pathway | leukocyte cell-cell adhesion | metabolic process | regulation of protein targeting | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | cellular protein localization | membrane invagination | regulation of vesicle-mediated transport | endocytosis | regulation of secretion | positive regulation of cell death | cell adhesion | toll-like receptor 4 signaling pathway | macrophage activation | immune response | organic substance metabolic process | cell death | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | regulation of phosphate metabolic process | cell-cell adhesion | regulation of regulated secretory pathway | positive regulation of intracellular transport | cell activation | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | leukocyte migration involved in inflammatory response | anatomical structure formation involved in morphogenesis | natural killer cell activation | signaling | regulation of transcription, DNA-templated | cell-matrix adhesion | protein localization | endodermal cell differentiation | endoderm development | anatomical structure morphogenesis | cellular macromolecule localization | regulation of developmental process | positive regulation of microglial cell activation | receptor-mediated endocytosis | developmental process | positive regulation of protein targeting to membrane | cellular extravasation | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of superoxide anion generation | receptor metabolic process | neutrophil mediated immunity | response to organonitrogen compound | formation of primary germ layer | positive regulation of nitric oxide biosynthetic process | cell-cell adhesion via plasma-membrane adhesion molecules | positive regulation of metabolic process | gastrulation | regulation of microglial cell activation | immune system process | cellular metabolic process | ameboidal-type cell migration | cellular response to organic substance | regulation of protein localization | regulation of cell death | neutrophil migration | aging | chemotaxis | phagocytosis | positive regulation of angiogenesis | regulation of cellular component organization | signal transduction | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | integral component of membrane | adherens junction | organelle membrane | tertiary granule | focal adhesion | cytoplasmic vesicle | cell | plasma membrane protein complex | intrinsic component of membrane | integrin complex | external side of plasma membrane | cytoplasm | cell-substrate junction | intracellular organelle | receptor complex | membrane microdomain | secretory granule membrane | ficolin-1-rich granule membrane | protein-containing complex | secretory vesicle | endomembrane system | plasma membrane | membrane raft | vesicle | extracellular exosome | cytoplasmic region | integrin alphaL-beta2 complex | specific granule | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | integrin alphaM-beta2 complex | vesicle membrane | extracellular space | cell periphery | cell-substrate adherens junction | tertiary granule membrane | plasma membrane raft | protein complex involved in cell adhesion | intracellular vesicle | cell surface | intracellular | cell junction | specific granule membrane | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane