QuickView for ITGB3BP;jsessionid=6A6C250B9D09313D3DBBA9DB8CCCA049 (gene)

Gene Symbol:

ITGB3BP Homo sapiens

Full name:

integrin subunit beta 3 binding protein

Synonyms:

CENP-R, CENPR, HSU37139, NRIF3, TAP20, centromere protein R, beta 3 endonexin, beta3-endonexin, integrin beta 3 binding protein (beta3-endonexin), integrin beta-3-binding protein, nuclear receptor-interacting factor 3

Genomic Location:

Chr 1: 63679050-63761423

Description:

This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signalin...

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This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA1_03 ,  RSRFC4_01 ,  YATGNWAAT_OCT_C ,  HFH1_01 ,  RSRFC4_Q2 ,  MEIS1BHOXA9_01 ,  TAAYNRNNTCC_UNKNOWN ,  CTAWWWATA_RSRFC4_Q2 ,  MEF2_02 ,  TATAAA_TATA_01 ,  CEBPDELTA_Q6 ,  RYTGCNWTGGNR_UNKNOWN ,  DBP_Q6 ,  PAX2_01 ,  CAGGTA_AREB6_01 ,  MEF2_01 ,  RFX1_02 ,  AREB6_01 ,  GATA6_01 ,  PAX6_01 ,  HMEF2_Q6 ,  CETS1P54_01 ,  TAATTA_CHX10_01 ,  YTAAYNGCT_UNKNOWN ,  CHOP_01 ,  TBP_01 ,  ELK1_02 ,  BRN2_01 ,  GTTNYYNNGGTNA_UNKNOWN ,  CEBPGAMMA_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-151 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

1p31.3

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