QuickView for ITGB4 (gene)

Gene Symbol:

ITGB4 Homo sapiens

Full name:

integrin subunit beta 4

Synonyms:

CD104, GP150, integrin beta-4, CD104 antigen

Genomic Location:

Chr 17: 71229111-71265494

Description:

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene ...

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Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  SMTTTTGT_UNKNOWN ,  TGANTCA_AP1_C ,  GCANCTGNY_MYOD_Q6 ,  LYF1_01 ,  NFKAPPAB_01 ,  CACCCBINDINGFACTOR_Q6 ,  GGGYGTGNY_UNKNOWN ,  CAGGTG_E12_Q6 ,  MYOD_Q6 ,  BACH2_01 ,  CATRRAGC_UNKNOWN ,  AREB6_03 ,  BACH1_01 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  PAX_Q6 ,  AACTTT_UNKNOWN ,  AP1_Q4_01 ,  NFKB_C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-409-5p

Cytogenetic Map:

17q25.1

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