QuickView for ITSN1 (gene)

Gene Symbol:

ITSN1 Homo sapiens

Full name:

intersectin 1

Synonyms:

ITSN, SH3D1A, SH3P17, intersectin-1, SH3 domain-containing protein 1A, Src homology 3 domain-containing protein, human intersectin-SH3 domain-containing protein SH3P17, intersectin 1 (SH3 domain protein), intersectin 1 short form variant 3, intersectin 1 short form variant, 11, intersectin short variant 12

Genomic Location:

Chr 21: 33936654-34183479

Description:

The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact w...

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The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ACAACCT_MIR453 ,  OCT1_07 ,  PAX4_04 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TTTGCAC_MIR19A_MIR19B ,  OCT1_B ,  MYOD_01 ,  CCCAGAG_MIR326 ,  RSRFC4_01 ,  OCT1_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  YTATTTTNR_MEF2_02 ,  GTGACTT_MIR224 ,  CAGTGTT_MIR141_MIR200A ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  CTAWWWATA_RSRFC4_Q2 ,  OCT1_Q5_01 ,  OCT_C ,  HEB_Q6 ,  CEBP_Q2 ,  RYTGCNWTGGNR_UNKNOWN ,  GCTTGAA_MIR498 ,  TTGGAGA_MIR5155P_MIR519E ,  GGGYGTGNY_UNKNOWN ,  GGATTA_PITX2_Q2 ,  RFX1_02 ,  RRAGTTGT_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  GGCNKCCATNK_UNKNOWN ,  GACAATC_MIR219 ,  ACTGCCT_MIR34B ,  ACTAYRNNNCCCR_UNKNOWN ,  ACTGCAG_MIR173P ,  GFI1_01 ,  POU3F2_02 ,  TGATTTRY_GFI1_01 ,  CAGCTG_AP4_Q5 ,  CTGTTAC_MIR194 ,  AACTTT_UNKNOWN ,  ACAGGGT_MIR10A_MIR10B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b

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Cytogenetic Map:

21q22.11

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