QuickView for Il27ra (gene)

Gene Symbol:

IL27RA Homo sapiens

Full name:

interleukin 27 receptor subunit alpha

Synonyms:

CRL1, IL-27RA, IL27R, TCCR, WSX1, zcytor1, interleukin-27 receptor subunit alpha, IL-27 receptor subunit alpha, IL-27R subunit alpha, IL-27R-alpha, T-cell cytokine receptor type 1, class I cytokine receptor, cytokine receptor WSX-1, cytokine receptor-like 1, interleukin 27 receptor, alpha, type I T-cell cytokine receptor

Genomic Location:

Chr 19: 14003262-14025026

Description:

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcript...

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In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFKAPPAB_01 ,  NFKB_Q6_01 ,  NFKB_C

Cytogenetic Map:

19p13.12

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