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QuickView for Iloprost (compound)


PubChem
Name: Iloprost
PubChem Compound ID: 10937300
Description: An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation.
Molecular formula: C22H32O4
Molecular weight: 360.487 g/mol
DrugBank
Identification
Name: Iloprost
Name (isomeric): DB01088
Drug Type: small molecule
Description: An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation.
Brand: Ventavis
Category: Antihypertensive Agents
CAS number: 78919-13-8
Pharmacology
Indication: Used for the treatment of pulmonary arterial hypertension.
Pharmacology:
Iloprost is a synthetic analogue of prostacyclin PGI2. Iloprost dilates systemic and pulmonary arterial vascular beds. It also affects platelet aggregation but the relevance of this effect to the treatment of pulmonary hypertension is unknown. The two diastereoisomers of iloprost differ in their potency in dilating blood vessels, with the 4S isomer...
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Mechanism of Action:
Iloprost is a second generation structural analog of prostacyclin (PGI) with about ten-fold greater potency than the first generation stable analogs, such as carbaprostacyclin. Iloprost binds with equal affinity to human prostacyclin (Prostanoid IP) and prostaglandin EP1 receptors. Iloprost constricts the ilium and fundus circular smooth muscle as ...
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Absorption: Rapidly absorbed with bioavailability of 63%
Protein binding: 60%
Biotransformation: Primarily hepatic. Iloprost is metabolized principally via beta-oxidation of the carboxyl side chain.
Half Life: 20-30 minutes
Clearance: 20 mL/min/kg [Normal subjects]
Toxicity: Overdoses can lead to hypotension, headache, flushing, nausea, vomiting, and diarrhea.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
TrandolaprilThe prostacyclin analogue, Iloprost, may increase the hypotensive effect of Trandolapril.

Targets


Transporters