QuickView for Interleukin 10 (gene)

Gene Symbol:

IL10 Homo sapiens

Full name:

interleukin 10

Synonyms:

CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin-10, T-cell growth inhibitory factor, cytokine synthesis inhibitory factor

Genomic Location:

Chr 1: 205007571-205012462

Description:

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, prolifera...

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The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP1_C ,  TFIIA_Q6 ,  TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  P53_DECAMER_Q2 ,  YTATTTTNR_MEF2_02 ,  YNTTTNNNANGCARM_UNKNOWN ,  XBP1_01 ,  WGTTNNNNNAAA_UNKNOWN ,  TAAYNRNNTCC_UNKNOWN ,  TATAAA_TATA_01 ,  NFE2_01 ,  CEBPB_01 ,  TCTGATA_MIR361 ,  ATACCTC_MIR202 ,  PXR_Q2 ,  AP1_Q4 ,  GATA4_Q3 ,  TATA_01 ,  AP1_Q2 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  AP1_Q4_01 ,  CEBPGAMMA_Q6 ,  TATTATA_MIR374 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-374

Cytogenetic Map:

1q32.1

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