QuickView for Ire1p (gene)
- Gene Symbol:
- ERN1
Homo sapiens - Full name:
- endoplasmic reticulum to nucleus signaling 1
- Synonyms:
- IRE1, IRE1P, IRE1a, hIRE1p, serine/threonine-protein kinase/endoribonuclease IRE1, ER to nucleus signalling 1, inositol-requiring 1, inositol-requiring enzyme 1, inositol-requiring protein 1, ire1-alpha, protein kinase/endoribonuclease
- Genomic Location:
- Chr 17: 59474122-59561234
- Description:
-
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling path...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Pan troglodytes , Bos taurus , Danio rerio , Canis lupus familiaris , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
POU6F1_01 , AP3_Q6 , NFKAPPAB_01 , TTF1_Q6 , NFKAPPAB65_01 , RP58_01 , CAGGTG_E12_Q6 , AP4_Q6 , YKACATTT_UNKNOWN , E47_01
- Cytogenetic Map:
-
17q23.3
GO Molecular Function
ADP binding | nuclease activity | cation binding | magnesium ion binding | platelet-derived growth factor receptor binding | enzyme binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | hydrolase activity | carbohydrate derivative binding | protein serine/threonine kinase activity | ribonuclease activity | catalytic activity | ATP binding | Hsp70 protein binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | endoribonuclease activity | protein homodimerization activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | endonuclease activity | transferase activity | Hsp90 protein binding | purine ribonucleotide binding | adenyl ribonucleotide binding | growth factor receptor binding | drug binding | kinase activity | heat shock protein binding | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | positive regulation of endoplasmic reticulum unfolded protein response | regulation of JUN kinase activity | positive regulation of smooth muscle cell proliferation | response to endoplasmic reticulum stress | cellular response to glucose stimulus | RNA processing | regulation of endoplasmic reticulum unfolded protein response | intracellular signal transduction | mRNA cleavage | nuclease activity | peptidyl-serine trans-autophosphorylation | peptidyl-amino acid modification | regulation of autophagy | negative regulation of cellular process | regulation of MAP kinase activity | cellular chemical homeostasis | glucose homeostasis | positive regulation of phosphate metabolic process | positive regulation of vascular smooth muscle cell proliferation | cellular process | organic substance catabolic process | cellular homeostasis | positive regulation of protein kinase activity | endoplasmic reticulum unfolded protein response | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | endothelial cell proliferation | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | catabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to unfolded protein | response to topologically incorrect protein | cellular aromatic compound metabolic process | MAPK cascade | mRNA catabolic process | cellular response to topologically incorrect protein | protein trans-autophosphorylation | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | RNA splicing | cellular response to vascular endothelial growth factor stimulus | JNK cascade | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | regulation of response to endoplasmic reticulum stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | positive regulation of RNA splicing | response to glucose | protein serine/threonine kinase activity | programmed cell death | cellular nitrogen compound metabolic process | regulation of macroautophagy | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | protein modification process | mRNA metabolic process | ribonuclease activity | cellular biosynthetic process | macromolecule modification | nucleobase-containing compound catabolic process | activation of protein kinase activity | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | apoptotic process | nitrogen compound metabolic process | regulation of signal transduction | cellular glucose homeostasis | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of gene expression | cellular response to stress | cell cycle | RNA catabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | protein autophosphorylation | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | positive regulation of intracellular signal transduction | cell proliferation | biosynthetic process | stress-activated MAPK cascade | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | aromatic compound catabolic process | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | regulation of protein phosphorylation | regulation of RNA metabolic process | apoptotic signaling pathway | positive regulation of molecular function | endoribonuclease activity | activation of MAPK activity | protein metabolic process | positive regulation of protein modification process | response to organic substance | cell cycle arrest | epithelial cell proliferation | regulation of kinase activity | regulation of intracellular signal transduction | cellular macromolecule catabolic process | IRE1-mediated unfolded protein response | peptidyl-serine autophosphorylation | metabolic process | regulation of RNA splicing | RNA phosphodiester bond hydrolysis, endonucleolytic | regulation of RNA biosynthetic process | cellular response to carbohydrate stimulus | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | chemical homeostasis | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | cell death | negative regulation of gene expression | RNA phosphodiester bond hydrolysis | gene expression | endonuclease activity | positive regulation of kinase activity | regulation of phosphate metabolic process | insulin metabolic process | transcription, DNA-templated | regulation of JNK cascade | positive regulation of MAPK cascade | negative regulation of cell cycle | regulation of stress-activated MAPK cascade | regulation of cell communication | signaling | regulation of transcription, DNA-templated | positive regulation of phosphorylation | cellular protein metabolic process | response to unfolded protein | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | kinase activity | peptidyl-serine phosphorylation | cellular protein modification process | heterocycle metabolic process | positive regulation of JUN kinase activity | mRNA splicing, via endonucleolytic cleavage and ligation | positive regulation of metabolic process | cellular metabolic process | mRNA processing | cellular response to organic substance | activation of JUN kinase activity | regulation of smooth muscle cell proliferation | response to carbohydrate | carbohydrate homeostasis | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | mRNA cleavage involved in mRNA processing | cellular response to growth factor stimulus | macromolecule metabolic process | positive regulation of response to endoplasmic reticulum stress | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | organelle inner membrane | intracellular membrane-bounded organelle | Ire1 complex | catalytic complex | organelle membrane | nuclear membrane | protein kinase complex | cell | integral component of endoplasmic reticulum membrane | nuclear inner membrane | intrinsic component of membrane | cytoplasm | intracellular organelle | intrinsic component of endoplasmic reticulum membrane | endoplasmic reticulum | IRE1-RACK1-PP2A complex | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | nuclear envelope | transferase complex | mitochondrion | AIP1-IRE1 complex | serine/threonine protein kinase complex | membrane-bounded organelle | nucleus | organelle | IRE1-TRAF2-ASK1 complex | intracellular | membrane
