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PubChem
| Name: | Iron |
|---|---|
| PubChem Compound ID: | 23925 |
| Description: | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Molecular formula: | Fe |
| Molecular weight: | 55.845 g/mol |
| Synonyms: |
Fe(Ii) Ion; C00023; 73135-38-3; Fe(Iii) Atom; 14067-02-8; Carbonyl iron; Ancor en 80/150; PZh3M; 129048-51-7; EINECS 231-096-4.
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DrugBank
Identification
| Name: | Iron |
|---|---|
| Name (isomeric): | DB01592 |
| Drug Type: | small molecule |
| Description: | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Brand: | Nephro-Fer, Feronate, Ferrousal, Ferro-Time, Feosol, Ircon, Siderol, Fer-In-Sol, Fergon, Ferretts, Hemocyte, Fe-40, Ferro-Caps, Yieronia, Feratab, Slow Fe, Mol-Iron, Feostat, Ed-In-Sol, Vitedyn-Slo |
| Category: | Iron Supplement, Trace Elements, Antianemic Agents |
| CAS number: | 7439-89-6 |
Pharmacology
| Indication: | Used in preventing and treating iron-deficiency anemia. |
|---|---|
| Pharmacology: | The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities. |
| Mechanism of Action: | Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia. |
| Absorption: | The efficiency of absorption depends on the salt form, the amount administered, the dosing regimen and the size of iron stores. Subjects with normal iron stores absorb 10% to 35% of an iron dose. Those who are iron deficient may absorb up to 95% of an iron dose. |
| Toxicity: | Acute iron overdosage can be divided into four stages. In the first stage, which occurs up to six hours after ingestion, the principal symptoms are vomiting and diarrhea. Other symptoms include hypotension, tachycardia and CNS depression ranging from lethargy to coma. The second phase may occur at 6-24 hours after ingestion and is characterized by a temporary remission. In the third phase, gastrointestinal symptoms recur accompanied by shock, metabolic acidosis, coma, hepatic necrosis and jaundice, hypoglycemia, renal failure and pulmonary edema. The fourth phase may occur several weeks after ingestion and is characterized by gastrointestinal obstruction and liver damage. In a young child, 75 milligrams per kilogram is considered extremely dangerous. A dose of 30 milligrams per kilogram can lead to symptoms of toxicity. Estimates of a lethal dosage range from 180 milligrams per kilogram and upwards. A peak serum iron concentration of five micrograms or more per ml is associated with moderate to severe poisoning in many. |
| Affected organisms: | Humans and other mammals |
Interactions
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