QuickView for Irx5 (gene)

Gene Symbol:

IRX5 Homo sapiens

Full name:

iroquois homeobox 5

Synonyms:

HMMS, IRX-2a, IRXB2, iroquois-class homeodomain protein IRX-5, homeodomain protein IRX-2A, homeodomain protein IRXB2

Genomic Location:

Chr 16: 53522612-53525898

Description:

This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repola...

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This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  MYOD_Q6_01 ,  HNF3ALPHA_Q6 ,  TFIIA_Q6 ,  GATA3_01 ,  YATGNWAAT_OCT_C ,  ZF5_01 ,  SMAD3_Q6 ,  GCANCTGNY_MYOD_Q6 ,  AREB6_04 ,  STAT6_01 ,  E2A_Q2 ,  GCCATNTTG_YY1_Q6 ,  WHN_B ,  GTACAGG_MIR486 ,  CTTTGTA_MIR524 ,  STAT3_02 ,  GGATTA_PITX2_Q2 ,  CAGGTG_E12_Q6 ,  HNF3_Q6 ,  EVI1_05 ,  GGGCGGR_SP1_Q6 ,  E47_01 ,  TGCCAAR_NF1_Q6 ,  SPZ1_01 ,  TGTTTGY_HNF3_Q6 ,  GATA1_02 ,  KCCGNSWTTT_UNKNOWN ,  RNGTGGGC_UNKNOWN ,  HMGIY_Q6 ,  CEBP_Q3 ,  TAATTA_CHX10_01 ,  YTAATTAA_LHX3_01 ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  CRX_Q4 ,  ATGTAGC_MIR221_MIR222 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-486 ,  Predicted Gene Targets for miR-490

Cytogenetic Map:

16q12.2

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