QuickView for Isl1 (gene)

Gene Symbol:

ISL1 Homo sapiens

Full name:

ISL LIM homeobox 1

Synonyms:

ISLET1, Isl-1, insulin gene enhancer protein ISL-1, ISL1 transcription factor, LIM/homeodomain, islet-1

Genomic Location:

Chr 5: 50714715-50726321

Description:

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor ...

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This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  OCT1_07 ,  RTAAACA_FREAC2_01 ,  OCT1_05 ,  SMTTTTGT_UNKNOWN ,  HNF1_01 ,  TTANTCA_UNKNOWN ,  OCT1_04 ,  GATA3_01 ,  FOXO4_01 ,  GATA_Q6 ,  YATGNWAAT_OCT_C ,  TTTTGAG_MIR373 ,  GATA_C ,  GCANCTGNY_MYOD_Q6 ,  EVI1_04 ,  TAAYNRNNTCC_UNKNOWN ,  GATAAGR_GATA_C ,  HNF1_C ,  CTTTGA_LEF1_Q2 ,  MYCMAX_B ,  OCT1_Q5_01 ,  OCT_C ,  GATA1_04 ,  ACTGTGA_MIR27A_MIR27B ,  TCTAGAG_MIR517 ,  EVI1_03 ,  OCT1_Q6 ,  TTGGAGA_MIR5155P_MIR519E ,  TCCCRNNRTGC_UNKNOWN ,  CATTTCA_MIR203 ,  GGATTA_PITX2_Q2 ,  ALPHACP1_01 ,  GCTCTTG_MIR335 ,  EVI1_02 ,  TST1_01 ,  ZID_01 ,  EVI1_05 ,  GCAAAAA_MIR129 ,  ATF3_Q6 ,  GACAATC_MIR219 ,  NFY_01 ,  LMO2COM_02 ,  GATA6_01 ,  OCT1_03 ,  E2F1_Q3_01 ,  IRF_Q6 ,  E47_01 ,  GCCNNNWTAAR_UNKNOWN ,  SOX5_01 ,  GACTGTT_MIR212_MIR132 ,  GATA1_02 ,  NCX_01 ,  EN1_01 ,  TTGCCAA_MIR182 ,  POU3F2_02 ,  AACATTC_MIR4093P ,  TTGTTT_FOXO4_01 ,  GR_01 ,  AP4_Q6_01 ,  ATF1_Q6 ,  CHOP_01 ,  CAAGGAT_MIR362 ,  ARGGGTTAA_UNKNOWN ,  WTTGKCTG_UNKNOWN ,  ER_Q6_01 ,  TAANNYSGCG_UNKNOWN ,  CAGCTG_AP4_Q5 ,  FOXM1_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  HNF1_Q6 ,  EVI1_01 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-325 ,  Predicted Gene Targets for miR-382 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-362 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

5q11.1

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