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PubChem
| Name: | Isoflurane |
|---|---|
| PubChem Compound ID: | 11095291 |
| Description: | A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. |
| Molecular formula: | C3H2ClF5O |
| Molecular weight: | 184.492 g/mol |
| Synonyms: |
ZINC03872952
|
DrugBank
Identification
| Name: | Isoflurane |
|---|---|
| Name (isomeric): | DB00753 |
| Drug Type: | small molecule |
| Description: | A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. |
| Brand: | Isofluranum [INN-Latin], Isoflurane [Usan:Ban:Inn:Jan], Aerrane, Ethane, Forene, Forane |
| Category: | Anesthetics, Inhalation, General Anesthetics, Anesthetics |
| CAS number: | 26675-46-7 |
Pharmacology
| Indication: | For induction and maintenance of general anesthesia. |
|---|---|
| Pharmacology: |
Isoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potenti...
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| Mechanism of Action: |
Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH de...
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| Biotransformation: | Minimal |
| Toxicity: | LC50=15300 ppm/3 hrs (inhalation by rat) |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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